Samanta Jayanta, Sharma Vishal
Jayanta Samanta, Vishal Sharma, Department of Gastro-enterology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.
World J Clin Cases. 2015 Feb 16;3(2):125-31. doi: 10.12998/wjcc.v3.i2.125.
Dengue has emerged as an important arboviral disease with significant impact on the disease burden in population residing in tropical countries. Dengue is spread by the bite of Aedes mosquito. The virus seems to have some hepatotoxic effects. Affliction of liver in form of derangements in the liver function tests is common and may include mild elevations in serum bilirubin, elevated transaminases and derangements in serum albumin. Although asymptomatic in most cases, clinical manifestations like jaundice, and acute liver failure (ALF) may occasionally complicate the clinical picture. Indeed, dengue has been implicated as an important cause of ALF in endemic countries. The present review focuses on the hepatic manifestations and the pathogenesis of the liver injury in dengue.
登革热已成为一种重要的虫媒病毒病，对热带国家居民的疾病负担产生重大影响。登革热通过伊蚊叮咬传播。该病毒似乎具有一些肝毒性作用。肝功能检查出现紊乱形式的肝脏受累很常见，可能包括血清胆红素轻度升高、转氨酶升高以及血清白蛋白紊乱。虽然在大多数情况下无症状，但黄疸和急性肝衰竭（ALF）等临床表现偶尔会使临床情况复杂化。事实上，在流行国家，登革热已被认为是急性肝衰竭的一个重要原因。本综述重点关注登革热的肝脏表现及肝损伤的发病机制。
