Department of Tropical Pediatric, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Pathog Glob Health. 2013 Apr;107(3):110-5. doi: 10.1179/2047773213Y.0000000080.
The relationships between allergic diseases and helminth infections are inconsistent. Some studies have suggested that helminth infections induce or increase the severity of atopic diseases. Other studies report that children infected with some helminths have lower prevalence and milder atopic symptoms. Expanding our knowledge on the mechanism of immunological modification as a result of helminth infection, and understanding the interaction between helminth infections and allergic diseases will be useful for developing potentially new treatments using some helminths, and for evaluating the risks and benefits of eradicating helminth infections in endemic areas. This article reviews current knowledge on the mechanisms of allergic disease, the immunological modifications that result from helminth infections, and clinical evidence of the effects of these infections on allergic diseases.
过敏疾病与寄生虫感染之间的关系并不一致。一些研究表明寄生虫感染会诱发或加重特应性疾病。其他研究则报告称，感染某些寄生虫的儿童其特应性症状的患病率较低且症状较轻。扩大我们对寄生虫感染导致免疫调节机制的认识，并了解寄生虫感染与过敏疾病之间的相互作用，将有助于开发利用某些寄生虫的潜在新疗法，并评估在寄生虫感染流行地区消除寄生虫感染的风险和获益。本文综述了过敏疾病的发病机制、寄生虫感染引起的免疫调节，以及这些感染对过敏疾病影响的临床证据。
