Mohammed Suha Haithem, Jabbr Azza Sajid, Ibrahim Nawal Khalil
Department of Clinical Laboratory Sciences, College of Pharmacy, University of Basrah, Iraq.
Department of Pharmacology and Toxicology, College of Pharmacy, University of Basrah, Iraq.
Respir Med Case Rep. 2021 Nov 10;34:101552. doi: 10.1016/j.rmcr.2021.101552. eCollection 2021.
There is strong evidence for a causal relationship between helminthes infection and allergic disease like asthma due to the similarity in the way they respond. This study aimed to investigate the effects of Ascaris infection on pulmonary function tests (PFTs) to reveal the relationship between ascariasis and asthma in children.
This a randomized-control study conducted in Basrah City, Iraq, in which four groups of a total of 490 children were enrolled: Group1 included 120 normal children; Group 2 included 135 asthmatic children; Group 3 who were 150 Ascaris infected children and group G4 included 85 asthmatic and Ascaris infected. PFTs, IgE level, differential blood count and parasitic examination were done for all groups.
Both group2 and 4, which included asthmatic children showed a significant decrease in PFT (P > 0.05),while the PFT of parasitic infected group was not affected. There were no significant changes in WBC, eosinophils and IgE between asthmatic and parasitic infected groups.
Ascaris infection could induce the inflammatory immune response in children, but couldn't cause a significant effect on pulmonary function tests in these children; The impairment in PFT was due to asthma disease and not correlated to ascariasis.
由于蠕虫感染与哮喘等过敏性疾病的反应方式相似，有充分证据表明它们之间存在因果关系。本研究旨在调查蛔虫感染对肺功能测试（PFT）的影响，以揭示儿童蛔虫病与哮喘之间的关系。
这是一项在伊拉克巴士拉市进行的随机对照研究，共纳入490名儿童，分为四组：第一组包括120名正常儿童；第二组包括135名哮喘儿童；第三组为150名感染蛔虫的儿童，第四组包括85名哮喘且感染蛔虫的儿童。对所有组进行了肺功能测试、免疫球蛋白E（IgE）水平、血常规和寄生虫检查。
包括哮喘儿童的第二组和第四组的肺功能测试均显著下降（P>0.05），而寄生虫感染组的肺功能测试未受影响。哮喘组和寄生虫感染组之间的白细胞、嗜酸性粒细胞和免疫球蛋白E无显著变化。
蛔虫感染可诱导儿童的炎症免疫反应，但对这些儿童的肺功能测试无显著影响；肺功能测试的损害是由于哮喘疾病，与蛔虫病无关。
