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使用类固醇预防恰加斯病患者对苯唑哒嗪的皮肤反应。

The use of steroids to prevent cutaneous reactions to benznidazole in patients with Chagas disease.

机构信息

Division of Infectious Diseases, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Spain.

出版信息

Pathog Glob Health. 2013 Apr;107(3):157-60. doi: 10.1179/2047773213Y.0000000081.

DOI:10.1179/2047773213Y.0000000081
PMID:23683371
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4003594/
Abstract

The treatment of Chagas disease is limited by the frequent cutaneous side effects of benznidazole. We tested the use of steroids plus escalating doses of benznidazole to prevent this complication in 17 adult patients with chronic Trypanosoma cruzi infection and found extremely good tolerance. A randomized trial is warranted.

摘要

治疗恰加斯病受到苯硝唑频繁引起皮肤副作用的限制。我们测试了类固醇加递增剂量苯硝唑预防 17 例慢性克氏锥虫感染成年患者这种并发症,发现耐受性极好。有必要进行随机试验。

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The use of steroids to prevent cutaneous reactions to benznidazole in patients with Chagas disease.使用类固醇预防恰加斯病患者对苯唑哒嗪的皮肤反应。
Pathog Glob Health. 2013 Apr;107(3):157-60. doi: 10.1179/2047773213Y.0000000081.
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Chagas Disease: Epidemiology, Diagnosis, and Treatment.恰加斯病:流行病学、诊断与治疗。
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Does Progressive Introduction of Benznidazole Reduce the Chance of Adverse Events in the Treatment of Chagas Disease?苯硝唑的逐步引入是否降低了治疗恰加斯病不良事件的机会?
Am J Trop Med Hyg. 2019 Jun;100(6):1477-1481. doi: 10.4269/ajtmh.18-0638.
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Safety Profile of Benznidazole in the Treatment of Chronic Chagas Disease: Experience of a Referral Centre and Systematic Literature Review with Meta-Analysis.苯硝唑治疗慢性恰加斯病的安全性概况:一家转诊中心的经验和系统文献综述与荟萃分析。
Drug Saf. 2018 Nov;41(11):1035-1048. doi: 10.1007/s40264-018-0696-5.

本文引用的文献

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Pathog Glob Health. 2012 Sep;106(5):305-9. doi: 10.1179/2047773212Y.0000000046.
2
Radiocontrast media allergic reactions and interventional pain practice--a review.放射性对比造影剂过敏反应与介入性疼痛治疗——综述
Pain Physician. 2012 Sep-Oct;15(5):E665-75.
3
Prevention and handling of acute allergic and infusion reactions in oncology.肿瘤患者急性过敏和输注反应的预防和处理。
Ann Oncol. 2012 Sep;23 Suppl 10:x313-9. doi: 10.1093/annonc/mds314.
4
Safety of benznidazole use in the treatment of chronic Chagas' disease.苯唑达唑治疗慢性恰加斯病的安全性。
J Antimicrob Chemother. 2012 May;67(5):1261-6. doi: 10.1093/jac/dks027. Epub 2012 Feb 13.
5
Side effects of benznidazole treatment in a cohort of patients with Chagas disease in non-endemic country.在一个非流行国家的一组恰加斯病患者中使用苯硝唑治疗的副作用。
Rev Esp Quimioter. 2011 Sep;24(3):123-6.
6
Antitrypanosomal therapy for chronic Chagas' disease.慢性恰加斯病的抗锥虫治疗。
N Engl J Med. 2011 Jun 30;364(26):2527-34. doi: 10.1056/NEJMct1014204.
7
Chagas disease in Latin American migrants: a Spanish challenge.拉美裔移民中的恰加斯病:西班牙面临的挑战。
Clin Microbiol Infect. 2011 Jul;17(7):1108-13. doi: 10.1111/j.1469-0691.2010.03423.x. Epub 2010 Dec 14.
8
Tolerance of benznidazole in treatment of Chagas' disease in adults.苯硝唑治疗成人恰加斯病的耐受性。
Antimicrob Agents Chemother. 2010 Nov;54(11):4896-9. doi: 10.1128/AAC.00537-10. Epub 2010 Sep 7.
9
Usefulness of PCR for monitoring benznidazole response in patients with chronic Chagas' disease: a prospective study in a non-disease-endemic country.PCR 在监测慢性恰加斯病患者贝那唑嗪反应中的作用:一个非流行国家的前瞻性研究。
J Antimicrob Chemother. 2010 Aug;65(8):1759-64. doi: 10.1093/jac/dkq201. Epub 2010 Jun 11.
10
Successful treatment with posaconazole of a patient with chronic Chagas disease and systemic lupus erythematosus.成功使用泊沙康唑治疗慢性恰加斯病合并系统性红斑狼疮患者。
Am J Trop Med Hyg. 2010 Apr;82(4):583-7. doi: 10.4269/ajtmh.2010.09-0620.