Department of Ophthalmology & Visual Sciences, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong.
Ophthalmology. 2013 Sep;120(9):1909-14. doi: 10.1016/j.ophtha.2013.02.005. Epub 2013 May 15.
To measure choroidal thickness (CT) in myopic eyes using enhanced depth imaging (EDI).
A cross-sectional study.
Fifty-six consecutive patients with spherical equivalent refractive error of at least 6 diopters (D) were evaluated.
Enhanced depth imaging optical coherence tomography (OCT) images were obtained by positioning the spectral-domain OCT device close enough to the eye to acquire an enhanced signal of the choroidal layer. Choroidal depth was measured as the distance between the outer reflective retinal pigment epithelium (RPE) layer and the inner sclera border. Measurements were made in a horizontal fashion across the fovea at 500-μm intervals of the sections. The CT was measured at the subfoveal region in a horizontal fashion, 3 mm temporal to fovea and 3 mm nasal to fovea.
Correlations among CT with age, refractive error in diopters, and visual acuity in logarithm of the minimum angle of resolution (logMAR) were analyzed with linear mixed models.
The mean age of the 56 patients was 50.4 years (± 2.03 years standard deviation; interquartile range [IQR], 42-62 years), and the mean refractive error was -8.7 D (IQR, -6.1 to -11 D). The mean subfoveal CT was 118 μm (± 68 μm) and correlated negatively with age (P = 0.032) and refractive error (P = 0.011). Regression analysis suggested that subfoveal CT decreased by 11.9 μm for each decade of life and by 6.205 μm for each diopter of myopia. The subfoveal CT was inversely correlated with the logMAR visual acuity (P = 0.008), and visual acuity improved by 0.02 (logMAR) in a 10-μm increase in CT.
Choroidal thickness decreases with age and severity of myopia. Visual acuity decreases in line with decreasing subfoveal CT. A reduction in CT is related to aging and the severity of myopia, whereas visual acuity depends on subfoveal CT. Our study supports the theory that choroidal abnormality may play a key role in the pathogenesis of myopic degeneration.
FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
使用增强深度成像（EDI）测量近视眼中的脉络膜厚度（CT）。
横断面研究。
评估了 56 名连续的等效球镜屈光不正至少 6 屈光度（D）的患者。
通过将光谱域 OCT 设备放置在足够靠近眼睛的位置以获取脉络膜层的增强信号来获得增强深度成像光学相干断层扫描（OCT）图像。脉络膜深度被测量为外视网膜色素上皮（RPE）层和内巩膜边界之间的距离。在水平方向上以 500μm 的间隔在黄斑区进行测量。在水平方向上在黄斑下 3mm 处测量脉络膜厚度，在黄斑鼻侧 3mm 处。
用线性混合模型分析 CT 与年龄、屈光度和最小角分辨率对数视力（logMAR）之间的相关性。
56 名患者的平均年龄为 50.4 岁（±2.03 岁标准差；四分位距[IQR]，42-62 岁），平均屈光度为-8.7 D（IQR，-6.1 至-11 D）。黄斑下 CT 的平均值为 118μm（±68μm），与年龄（P=0.032）和屈光度（P=0.011）呈负相关。回归分析表明，脉络膜下 CT 每 10 年减少 11.9μm，每 6.205μm 近视增加 1 屈光度。黄斑下 CT 与 logMAR 视力呈负相关（P=0.008），CT 增加 10μm 时，视力提高 0.02（logMAR）。
脉络膜厚度随年龄和近视程度的增加而降低。视力随黄斑下 CT 的减少而下降。CT 的减少与衰老和近视的严重程度有关，而视力取决于黄斑下 CT。我们的研究支持脉络膜异常可能在近视变性发病机制中起关键作用的理论。
作者在本文讨论的任何材料中均没有专有的或商业利益。
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