Department of Pharmaceutical Biology, University of Groningen, Groningen 9713AV, The Netherlands.
Trends Microbiol. 2013 Jul;21(7):315-6. doi: 10.1016/j.tim.2013.04.006. Epub 2013 May 14.
The susceptibility of Caenorhabditis elegans to different virulent phenotypes of Pseudomonas aeruginosa makes the worms an excellent model for studying host-pathogen interactions. Including the recently described liquid killing, five different killing assays are now available offering superb possibilities for performing high-throughput screens for novel antibiotics using a whole-body infection system.
秀丽隐杆线虫对铜绿假单胞菌不同毒力表型的易感性使线虫成为研究宿主-病原体相互作用的极佳模型。包括最近描述的液体致死,现在有五种不同的致死测定可供使用,为使用全身感染系统进行新型抗生素的高通量筛选提供了极好的可能性。