Department of Immunology, Monash University, Central Clinical School, Alfred Medical Research and Education Precinct (AMREP), 89 Commercial Road, Melbourne, Victoria 3004, Australia.
Cytokine Growth Factor Rev. 2013 Jun;24(3):203-15. doi: 10.1016/j.cytogfr.2013.04.003. Epub 2013 May 15.
The BAFF system plays a key role in the development of autoimmunity, especially in systemic lupus erythematosus (SLE). This often leads to the assumption that BAFF is mostly a B cell factor with a specific role in autoimmunity. Focus on BAFF and autoimmunity, driven by pharmaceutical successes with the recent approval of a novel targeted therapy Belimumab, has relegated other potential roles of BAFF to the background. Far from being SLE-specific, the BAFF system has a much broader relevance in infection, cancer and allergy. In this review, we provide the latest views on additional roles of the BAFF system in health and diseases, as well as an update on BAFF and autoimmunity, with particular focus on current clinical trials.
BAFF 系统在自身免疫的发展中起着关键作用，特别是在系统性红斑狼疮（SLE）中。这往往导致人们认为 BAFF 主要是一种 B 细胞因子，在自身免疫中具有特定的作用。由于最近批准了一种新型靶向治疗药物贝利木单抗（Belimumab）在制药方面取得了成功，因此对 BAFF 和自身免疫的关注已经将 BAFF 的其他潜在作用置于次要地位。BAFF 系统远非 SLE 所特有，它在感染、癌症和过敏等方面具有更广泛的相关性。在这篇综述中，我们提供了关于 BAFF 系统在健康和疾病中的其他作用的最新观点，以及对 BAFF 和自身免疫的最新更新，特别关注当前的临床试验。
