Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, H-6701 Szeged, Hungary.
FEBS Lett. 2013 Jun 27;587(13):1970-80. doi: 10.1016/j.febslet.2013.05.016. Epub 2013 May 16.
Heat stress is a common and, therefore, an important environmental impact on cells and organisms. While much attention has been paid to severe heat stress, moderate temperature elevations are also important. Here we discuss temperature sensing and how responses to heat stress are not necessarily dependent on denatured proteins. Indeed, it is clear that membrane lipids have a pivotal function. Details of membrane lipid changes and the associated production of signalling metabolites are described and suggestions made as to how the interconnected signalling network could be modified for helpful intervention in disease.
热应激是细胞和生物体常见且重要的环境影响因素。虽然人们已经关注了严重的热应激，但适度的温度升高也很重要。在这里，我们讨论温度感应以及热应激反应不一定依赖于变性蛋白质的机制。事实上，很明显，膜脂具有关键作用。本文详细描述了膜脂变化以及相关信号代谢物的产生，并就如何修改相互关联的信号网络以有助于疾病干预提出了建议。
