Löster H, Gründer W, Keller T, Seim H, Grommisch J, Müller F
Institut für Pathologische Biochemie, Bereichs Medizin, Karl-Marx-Universität Leipzig.
Z Med Lab Diagn. 1990;31(3):123-7.
31P-NMR spectroscopy is a method for continuous, noninvasive determination of high-energy phosphates in the intact organ. On the isolated Langendorff perfused rat heart the effect of L-carnitine on concentration of cytosolic ATP and phosphocreatine was studied under influence of a single or repeated periods of 20 min ischemia. On reperfusion the carnitine-treated hearts showed higher CP/Pi values and an increase of the energy index (CP + ATP)/(C) + ATP + Pi) then did control hearts. An improved ischemia tolerance was demonstrated.
31P-核磁共振波谱法是一种用于完整器官中高能磷酸盐的连续、非侵入性测定方法。在离体Langendorff灌注大鼠心脏上，研究了左旋肉碱在单次或重复20分钟缺血影响下对胞质ATP和磷酸肌酸浓度的作用。再灌注时，经肉碱处理的心脏显示出比对照心脏更高的CP/Pi值和能量指数（CP + ATP）/（C + ATP + Pi）增加。证明了缺血耐受性得到改善。
