de Duve Institute and Université Catholique de Louvain, Brussels, Belgium.
Mol Cell Endocrinol. 2013 Aug 15;375(1-2):10-3. doi: 10.1016/j.mce.2013.05.005. Epub 2013 May 16.
In 1963 Peter Karlson put forward the revolutionary "hormone-gene" hypothesis, which would change drastically the way in which steroid hormones were thought to act at the time. From a historical perspective, this review relates the acceptance of this initially controversial idea, the discovery of the steroid receptors and the key experiments that have led to the current understanding of the mechanism of steroid hormone action. It shows how, over 50years, the field has widened beyond all expectation and has contributed to major advances not only in endocrinology, but also in molecular biology, pharmacology and therapeutics.
1963 年，彼得·卡尔森（Peter Karlson）提出了革命性的“激素-基因”假说，这一假说彻底改变了当时人们对甾体激素作用方式的看法。从历史的角度来看，本文回顾了这一最初颇具争议的观点被接受的过程、甾体激素受体的发现，以及导致目前对甾体激素作用机制理解的关键实验。它展示了在过去的 50 多年里，该领域的发展是如何超出预期的，不仅在内分泌学领域，而且在分子生物学、药理学和治疗学领域都做出了重大贡献。
