Harrison R W, Lippman S S
Division of Endocrinology and Metabolism, University of Arkansas College of Medicine, Little Rock.
Hosp Pract (Off Ed). 1989 Sep 15;24(9):63-8, 70-1, 75-6. doi: 10.1080/21548331.1989.11703777.
Understanding how steroids work has led to improved comprehension of such derangements of hormonal regulation as testicular feminization. This knowledge has found practical application in the treatment of hormone-dependent cancers. Gene therapy, albeit still too primitive to correct steroid-response defects, promises to be a future mainstay of management.
对类固醇作用机制的了解,增进了我们对诸如睾丸女性化等激素调节紊乱的认识。这一知识已在激素依赖性癌症的治疗中得到实际应用。基因治疗虽然仍过于原始,无法纠正类固醇反应缺陷,但有望成为未来治疗的主要手段。