线粒体乙醛脱氢酶2基因中的Glu487Lys多态性与老年韩国男性心肌梗死有关。

A Glu487Lys polymorphism in the gene for mitochondrial aldehyde dehydrogenase 2 is associated with myocardial infarction in elderly Korean men.

作者信息

Jo Sangmee Ahn, Kim Eun-Kyung, Park Moon Ho, Han Changsu, Park Hyun-Young, Jang Yangsoo, Song Byung Joon, Jo Inho

机构信息

Center for Biomedical Sciences, National Institute of Health, 194 Tongil-Ro, Eunpyeong-gu, Seoul, South Korea.

出版信息

Clin Chim Acta. 2007 Jul;382(1-2):43-7. doi: 10.1016/j.cca.2007.03.016. Epub 2007 Mar 24.

DOI:10.1016/j.cca.2007.03.016

PMID:17459359

Abstract

BACKGROUND

A homozygous mutant (ALDH2*2/*2) of the gene for mitochondrial aldehyde dehydrogenase 2 (ALDH2) at codon 487 was reported to be associated with myocardial infarction (MI) among Japanese men. However, such an association has never been studied in a Korean population.

METHOD

The subjects consisted of 122 men (60-81 y) with MI recruited randomly from Yonsei University Medical Center, Korea. A total of 439 men (60-84 y) without MI were selected as controls from the Ansan Geriatric Study. ALDH2 genotypes were determined using the TaqMan fluorogenic 5' nuclease polymerase chain reaction assay.

RESULTS

Genotypes carrying the mutant ALDH2 allele (ALDH2*1/2 plus ALDH22/2) were significantly more frequent in patients with MI than in the controls (42.6% vs. 30.5%, P=0.0163). Multiple logistic regression analysis revealed that ALDH21/2 plus ALDH22/*2, together with abnormal high density lipoprotein cholesterol and elevated body mass index, was an independent risk factor for MI in elderly Korean men (odds ratio=1.976, 95% CI: 1.202-3.248).

CONCLUSIONS

ALDH2 polymorphisms may play an important role in the pathogenesis of MI in elderly Korean men.

摘要

背景

据报道，线粒体乙醛脱氢酶2（ALDH2）基因第487位密码子的纯合突变体（ALDH2*2/*2）与日本男性心肌梗死（MI）相关。然而，韩国人群中尚未有此类关联的研究。

方法

研究对象包括从韩国延世大学医学中心随机招募的122名患心肌梗死的男性（60 - 81岁）。从安山老年研究中选取439名无心肌梗死的男性（60 - 84岁）作为对照。采用TaqMan荧光5'核酸酶聚合酶链反应分析法测定ALDH2基因型。

结果

携带突变型ALDH2等位基因的基因型（ALDH2*1/2加ALDH22/2）在心肌梗死患者中显著高于对照组（42.6%对30.5%，P = 0.0163）。多因素逻辑回归分析显示，ALDH21/2加ALDH22/*2，以及异常高密度脂蛋白胆固醇和升高的体重指数，是韩国老年男性心肌梗死的独立危险因素（比值比 = 1.976，95%可信区间：1.202 - 3.248）。