Li Youqian, Zhong Wei, Liu Zhidong, Huang Changjing, Peng Junyin, Li Hanlin
Center for Cardiovascular Diseases, Meizhou People's Hospital, Meizhou Academy of Medical Sciences, Meizhou, People's Republic of China.
Guangdong Provincial Engineering and Technology Research Center for Molecular Diagnostics of Cardiovascular Diseases, Meizhou People's Hospital, Meizhou Academy of Medical Sciences, Meizhou, People's Republic of China.
Int J Gen Med. 2024 Aug 19;17:3591-3600. doi: 10.2147/IJGM.S475756. eCollection 2024.
Aldehyde dehydrogenase 2 (ALDH2) is a key catalytic enzyme involved in the aldehyde metabolism that plays an important role in the occurrence and development of acute myocardial infarction (AMI). However, the relationship of polymorphism and susceptibility to AMI may differ among different regions and populations, and it has not yet been reported in Hakka population. The purpose of the present study was to investigate it in this population.
Four hundred and nineteen AMI patients and 636 individuals without AMI were included in the present study. The rs671 polymorphism was genotyped using polymerase chain reaction (PCR)-microarray. Differences in rs671 genotypes and alleles between patients and controls were compared, and the relationship between rs671 genotypes and AMI risk was analyzed.
Patients with AMI had a lower frequency of rs671 G/G genotype (43.2% vs 52.7%, =0.003), and a higher G/A genotype (45.6% vs 38.5%, =0.025) than controls. And AMI patients had a lower frequency of rs671 G allele (66.0% vs 71.9%), and a higher A allele (34.0% vs 28.1%) (=0.004) than controls. Logistic regression analysis showed that overweight (body mass index (BMI)≥24.0 kg/m vs BMI 18.5-23.9 kg/m: odds ratio (OR) 2.046, 95% confidence interval (CI): 1.520-2.754, <0.001), history of hypertension (yes vs no: OR 3.464, 95% CI: 2.515-4.770, <0.001), rs671 G/A genotype (G/A vs G/G: OR 1.476, 95% CI: 1.102-1.976, =0.009), and A/A genotype (A/A vs G/G: OR 1.656, 95% CI: 1.027-2.668, =0.038) maybe the independent risk factors for AMI.
Overweight (BMI≥24.0 kg/m), a history of hypertension, and rs671 G/A or A/A genotypes increased the risk of developing AMI in Hakka population.
乙醛脱氢酶2（ALDH2）是参与醛代谢的关键催化酶，在急性心肌梗死（AMI）的发生发展中起重要作用。然而，不同地区和人群中多态性与AMI易感性的关系可能存在差异，且在客家人中尚未见报道。本研究旨在对此人群进行调查。
本研究纳入419例AMI患者和636例无AMI的个体。采用聚合酶链反应（PCR）-微阵列对rs671多态性进行基因分型。比较患者和对照组rs671基因型和等位基因的差异，并分析rs671基因型与AMI风险的关系。
AMI患者rs671 G/G基因型频率低于对照组（43.2%对52.7%，P=0.003），G/A基因型频率高于对照组（45.6%对38.5%，P=0.025）。AMI患者rs671 G等位基因频率低于对照组（66.0%对71.9%），A等位基因频率高于对照组（34.0%对28.1%）（P=0.004）。Logistic回归分析显示，超重（体重指数（BMI）≥24.0 kg/m²对BMI 18.5-23.9 kg/m²：比值比（OR）2.046，95%置信区间（CI）：1.520-2.754，P<0.001）、高血压病史（是对否：OR 3.464，95%CI：2.515-4.770，P<0.001）、rs671 G/A基因型（G/A对G/G：OR 1.476，95%CI：1.102-1.976，P=0.009）和A/A基因型（A/A对G/G：OR 1.656，95%CI：1.027-2.668，P=0.038）可能是AMI的独立危险因素。
超重（BMI≥24.0 kg/m²）、高血压病史以及rs671 G/A或A/A基因型增加了客家人发生AMI的风险。
