rs671 G/A and a/A Genotypes are Associated with the Risk of Acute Myocardial Infarction.

BACKGROUND

Aldehyde dehydrogenase 2 (ALDH2) is a key catalytic enzyme involved in the aldehyde metabolism that plays an important role in the occurrence and development of acute myocardial infarction (AMI). However, the relationship of polymorphism and susceptibility to AMI may differ among different regions and populations, and it has not yet been reported in Hakka population. The purpose of the present study was to investigate it in this population.

METHODS

Four hundred and nineteen AMI patients and 636 individuals without AMI were included in the present study. The rs671 polymorphism was genotyped using polymerase chain reaction (PCR)-microarray. Differences in rs671 genotypes and alleles between patients and controls were compared, and the relationship between rs671 genotypes and AMI risk was analyzed.

RESULTS

Patients with AMI had a lower frequency of rs671 G/G genotype (43.2% vs 52.7%, =0.003), and a higher G/A genotype (45.6% vs 38.5%, =0.025) than controls. And AMI patients had a lower frequency of rs671 G allele (66.0% vs 71.9%), and a higher A allele (34.0% vs 28.1%) (=0.004) than controls. Logistic regression analysis showed that overweight (body mass index (BMI)≥24.0 kg/m vs BMI 18.5-23.9 kg/m: odds ratio (OR) 2.046, 95% confidence interval (CI): 1.520-2.754, <0.001), history of hypertension (yes vs no: OR 3.464, 95% CI: 2.515-4.770, <0.001), rs671 G/A genotype (G/A vs G/G: OR 1.476, 95% CI: 1.102-1.976, =0.009), and A/A genotype (A/A vs G/G: OR 1.656, 95% CI: 1.027-2.668, =0.038) maybe the independent risk factors for AMI.

CONCLUSION

Overweight (BMI≥24.0 kg/m), a history of hypertension, and rs671 G/A or A/A genotypes increased the risk of developing AMI in Hakka population.