用于检测和治疗妇科癌症的产气荚膜梭菌肠毒素（CPE）和CPE结合域（c-CPE）。
Clostridium perfringens enterotoxin (CPE) and CPE-binding domain (c-CPE) for the detection and treatment of gynecologic cancers.
作者信息
Black Jonathan D, Lopez Salvatore, Cocco Emiliano, Schwab Carlton L, English Diana P, Santin Alessandro D
机构信息
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, PO Box 208063, New Haven, CT 06520-8063, USA.
Division of Gynecologic Oncology, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, 00128 Rome, Italy.
出版信息
Toxins (Basel). 2015 Apr 1;7(4):1116-25. doi: 10.3390/toxins7041116.
Abstract
Clostridium perfringens enterotoxin (CPE) is a three-domain polypeptide, which binds to Claudin-3 and Claudin-4 with high affinity. Because these receptors are highly differentially expressed in many human tumors, claudin-3 and claudin-4 may provide an efficient molecular tool to specifically identify and target biologically aggressive human cancer cells for CPE-specific binding and cytolysis. In this review we will discuss these surface proteins as targets for the detection and treatment of chemotherapy-resistant gynecologic malignancies overexpressing claudin-3 and -4 using CPE-based theranostic agents. We will also discuss the use of fluorescent c-CPE peptide in the operative setting for real time detection of micro-metastatic tumors during surgery and review the potential role of CPE in other medical applications.
摘要
产气荚膜梭菌肠毒素（CPE）是一种三结构域多肽，它能与紧密连接蛋白-3（Claudin-3）和紧密连接蛋白-4（Claudin-4）高亲和力结合。由于这些受体在许多人类肿瘤中存在高度差异表达，Claudin-3和Claudin-4可能为特异性识别和靶向具有生物学侵袭性的人类癌细胞提供一种有效的分子工具，以实现CPE特异性结合和细胞溶解。在本综述中，我们将讨论这些表面蛋白作为使用基于CPE的诊疗试剂检测和治疗过表达Claudin-3和Claudin-4的化疗耐药性妇科恶性肿瘤的靶点。我们还将讨论荧光c-CPE肽在手术环境中用于手术期间实时检测微转移肿瘤的应用，并综述CPE在其他医学应用中的潜在作用。
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