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本文引用的文献

1
Claudin-3 overexpression increases the malignant potential of colorectal cancer cells: roles of ERK1/2 and PI3K-Akt as modulators of EGFR signaling.Claudin-3 过表达增加结直肠癌细胞的恶性潜能：ERK1/2 和 PI3K-Akt 作为 EGFR 信号转导调节剂的作用。
PLoS One. 2013 Sep 19;8(9):e74994. doi: 10.1371/journal.pone.0074994. eCollection 2013.
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Claudins and other tight junction proteins.紧密连接蛋白和其他紧密连接蛋白。
Compr Physiol. 2012 Jul;2(3):1819-52. doi: 10.1002/cphy.c110045.
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Claudin-3 and claudin-4: distinct prognostic significance in triple-negative and luminal breast cancer.Claudin-3和Claudin-4：在三阴性和管腔型乳腺癌中的不同预后意义。
Appl Immunohistochem Mol Morphol. 2014;22(2):125-31. doi: 10.1097/PAI.0b013e31828d9d62.
4
Claudins overexpression in ovarian cancer: potential targets for Clostridium Perfringens Enterotoxin (CPE) based diagnosis and therapy.紧密连接蛋白在卵巢癌中的过表达：基于产气荚膜梭菌肠毒素（CPE）的诊断和治疗的潜在靶点。
Int J Mol Sci. 2013 May 17;14(5):10412-37. doi: 10.3390/ijms140510412.
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Claudin-6: a novel receptor for CPE-mediated cytotoxicity in ovarian cancer.Claudin-6：卵巢癌细胞中 CPE 介导细胞毒性的新型受体。
Oncogenesis. 2012 Nov 12;1(11):e33. doi: 10.1038/oncsis.2012.32.
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Human claudin-8 and -14 are receptors capable of conveying the cytotoxic effects of Clostridium perfringens enterotoxin.人紧密连接蛋白-8 和 -14 是能够传递梭状芽孢杆菌肠毒素细胞毒性作用的受体。
mBio. 2013 Jan 15;4(1):e00594-12. doi: 10.1128/mBio.00594-12.
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Cisplatin resistance: a cellular self-defense mechanism resulting from multiple epigenetic and genetic changes.顺铂耐药性：一种由多种表观遗传和遗传变化引起的细胞自我保护机制。
Pharmacol Rev. 2012 Jul;64(3):706-21. doi: 10.1124/pr.111.005637. Epub 2012 Jun 1.
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Novel Clostridium perfringens enterotoxin suicide gene therapy for selective treatment of claudin-3- and -4-overexpressing tumors.新型产气荚膜梭菌肠毒素自杀基因治疗用于选择性治疗 Claudin-3 和 Claudin-4 过表达肿瘤。
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9
Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results.叶酸受体-α靶向的卵巢癌术中肿瘤特异性荧光成像：首例人体研究结果。
Nat Med. 2011 Sep 18;17(10):1315-9. doi: 10.1038/nm.2472.
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Management strategies for recurrent platinum-resistant ovarian cancer.复发性铂耐药性卵巢癌的管理策略。
Drugs. 2011 Jul 30;71(11):1397-412. doi: 10.2165/11591720-000000000-00000.

用于检测和治疗妇科癌症的产气荚膜梭菌肠毒素（CPE）和CPE结合域（c-CPE）。

Clostridium perfringens enterotoxin (CPE) and CPE-binding domain (c-CPE) for the detection and treatment of gynecologic cancers.

作者信息

Black Jonathan D, Lopez Salvatore, Cocco Emiliano, Schwab Carlton L, English Diana P, Santin Alessandro D

机构信息

Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, PO Box 208063, New Haven, CT 06520-8063, USA.

Division of Gynecologic Oncology, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, 00128 Rome, Italy.

出版信息

Toxins (Basel). 2015 Apr 1;7(4):1116-25. doi: 10.3390/toxins7041116.

DOI:10.3390/toxins7041116
PMID:25835384
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4417958/
Abstract

Clostridium perfringens enterotoxin (CPE) is a three-domain polypeptide, which binds to Claudin-3 and Claudin-4 with high affinity. Because these receptors are highly differentially expressed in many human tumors, claudin-3 and claudin-4 may provide an efficient molecular tool to specifically identify and target biologically aggressive human cancer cells for CPE-specific binding and cytolysis. In this review we will discuss these surface proteins as targets for the detection and treatment of chemotherapy-resistant gynecologic malignancies overexpressing claudin-3 and -4 using CPE-based theranostic agents. We will also discuss the use of fluorescent c-CPE peptide in the operative setting for real time detection of micro-metastatic tumors during surgery and review the potential role of CPE in other medical applications.

摘要

产气荚膜梭菌肠毒素（CPE）是一种三结构域多肽，它能与紧密连接蛋白-3（Claudin-3）和紧密连接蛋白-4（Claudin-4）高亲和力结合。由于这些受体在许多人类肿瘤中存在高度差异表达，Claudin-3和Claudin-4可能为特异性识别和靶向具有生物学侵袭性的人类癌细胞提供一种有效的分子工具，以实现CPE特异性结合和细胞溶解。在本综述中，我们将讨论这些表面蛋白作为使用基于CPE的诊疗试剂检测和治疗过表达Claudin-3和Claudin-4的化疗耐药性妇科恶性肿瘤的靶点。我们还将讨论荧光c-CPE肽在手术环境中用于手术期间实时检测微转移肿瘤的应用，并综述CPE在其他医学应用中的潜在作用。