Hemorheology and Haemostasis Unit, Service of Clinical Pathology, La Fe University Hospital, Valencia, Spain.
Clin Hemorheol Microcirc. 2013 Jan 1;54(3):333-9. doi: 10.3233/CH-131738.
Red blood cell distribution width (RDW) is a routine parameter that reflects size variations in erythrocytes. High RDW has been associated with cardiovascular events and inflammatory diseases. However, no studies evaluating the association of RDW with systemic lupus erythematosus (SLE) have been published. We aimed to explore the association of RDW with inflammatory markers in SLE. As SLE is often associated with anaemia, we considered this factor in order to know whether RDW is related with inflammation, anaemia or both in SLE. The study included 105 SLE patients (7 men, 98 women; aged 15-73 years) and 105 controls (9 men, 96 women; aged 18-71 years). Patients were divided according to anaemia status (26 with, 79 without). Biochemical, hematological and inflammatory parameters (C-reactive protein (CRP), fibrinogen and erythrocyte aggregation (EA1)) were analyzed. SLE patients showed increased RDW, CRP and EA1 (p < 0.001), and decreased hemoglobin levels (p < 0.001) when compared with controls. RDW was higher in SLE patients with anaemia (a-SLE) as compared with those without anaemia (na-SLE) (p < 0.01) or controls (p < 0.001). CRP in a-SLE was higher than in controls (p < 0.01) but lower than in na-SLE (p < 0.05). In na-SLE RDW correlated directly with fibrinogen and CRP (p < 0.001), but not in a-SLE. Our results indicate that SLE patients show higher RDW irrespectively of anaemia status, and that RDW is influenced by both anaemia and inflammation, but the influence of anaemia is stronger.
红细胞分布宽度（RDW）是反映红细胞大小变化的常规参数。高 RDW 与心血管事件和炎症性疾病有关。然而，目前尚未有研究评估 RDW 与系统性红斑狼疮（SLE）之间的关系。我们旨在探讨 RDW 与 SLE 中炎症标志物的关系。由于 SLE 常伴有贫血，我们考虑到这一因素，以了解 RDW 是否与 SLE 中的炎症、贫血或两者均有关。该研究纳入了 105 例 SLE 患者（7 名男性，98 名女性；年龄 15-73 岁）和 105 名对照者（9 名男性，96 名女性；年龄 18-71 岁）。根据贫血状态将患者分为两组（26 例贫血，79 例无贫血）。分析了生化、血液学和炎症参数（C 反应蛋白（CRP）、纤维蛋白原和红细胞聚集（EA1））。与对照组相比，SLE 患者的 RDW、CRP 和 EA1 升高（p<0.001），血红蛋白水平降低（p<0.001）。与无贫血的 SLE 患者（na-SLE）或对照组相比，贫血的 SLE 患者（a-SLE）的 RDW 更高（p<0.01）。a-SLE 患者的 CRP 高于对照组（p<0.01），但低于 na-SLE 患者（p<0.05）。在 na-SLE 中，RDW 与纤维蛋白原和 CRP 呈直接相关（p<0.001），但在 a-SLE 中无相关性。我们的结果表明，无论贫血状态如何，SLE 患者的 RDW 均升高，且 RDW 受到贫血和炎症的双重影响，但贫血的影响更强。
