急性缺血性卒中急性期入院时红细胞分布宽度与卒中后疲劳的关系。
The relationship between red blood cell distribution width at admission and post-stroke fatigue in the acute phase of acute ischemic stroke.
作者信息
Peng Meidi, Chen Yupei, Chen Yan, Feng Koulan, Shen Haiyan, Huang Hongtao, Zhao Wenxuan, Zou Hua, Ji Jianan
机构信息
School of Medicine (School of Nursing), Nantong University, Nantong, China.
Department of Neurology, Nantong Third People's Hospital, Nantong University, Nantong, China.
出版信息
Front Neurol. 2022 Jul 29;13:922823. doi: 10.3389/fneur.2022.922823. eCollection 2022.
INTRODUCTION
Post-stroke fatigue (PSF) is a common complication in the patients with acute ischemic stroke (AIS). This prospective study aimed to investigate the relationship between red blood cell distribution width (RDW) at admission and PSF in the acute phase.
METHODS
The AIS patients were enrolled in Nantong Third People's Hospital, consecutively. PSF in the acute phase was scored according to the Fatigue Severity Scale. Levels of RDW were measured at admission. The associations were analyzed using multivariate regression and restricted cubic splines (RCS).
RESULTS
From April 2021 to March 2022, a total of 206 AIS patients (mean age, 69.3 ± 10.7 years; 52.9% men) were recruited. After the adjustment for potential confounding factors, RDW at admission remained the independent associated factor with PSF in the acute phase (OR [odds ratio], 1.635; 95% CI [confidence interval], 1.153-2.318; = 0.006). The linear dose-response associations of RDW with PSF in the acute phase were found, based on the RCS model ( for non-linearity = 0.372; for linearity = 0.037). These results remained significant in other models.
CONCLUSIONS
RDW at admission could serve as a novel biomarker of PSF in the acute phase of AIS.
引言
中风后疲劳（PSF）是急性缺血性中风（AIS）患者常见的并发症。这项前瞻性研究旨在探讨入院时红细胞分布宽度（RDW）与急性期PSF之间的关系。
方法
连续纳入南通第三人民医院的AIS患者。根据疲劳严重程度量表对急性期的PSF进行评分。入院时测量RDW水平。使用多变量回归和限制性立方样条（RCS）分析相关性。
结果
2021年4月至2022年3月，共招募了206例AIS患者（平均年龄69.3±10.7岁；52.9%为男性）。在对潜在混杂因素进行调整后，入院时的RDW仍然是急性期PSF的独立相关因素（比值比[OR]，1.635；95%置信区间[CI]，1.153-2.318；P = 0.006）。基于RCS模型发现了RDW与急性期PSF之间的线性剂量反应关系（非线性检验P = 0.372；线性检验P = 0.037）。这些结果在其他模型中仍然显著。
结论
入院时的RDW可作为AIS急性期PSF的一种新型生物标志物。
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