红细胞分布宽度是评估系统性红斑狼疮疾病活动的潜在指标。
Red blood cell distribution width is a potential index to assess the disease activity of systemic lupus erythematosus.
机构信息
Department of Laboratory Diagnosis, Changhai Hospital, Second Military Medical University, Shanghai, PR China; Department of Laboratory Diagnosis, Changzheng Hospital, Second Military Medical University, Shanghai, PR China; Department of Laboratory Medicine, General Hospital of Ji'nan Military Command Region, Ji'nan, PR China.
出版信息
Clin Chim Acta. 2013 Oct 21;425:202-5. doi: 10.1016/j.cca.2013.08.007. Epub 2013 Aug 15.
BACKGROUND
General population-based investigations have revealed that red blood cell distribution width (RDW) is associated with inflammatory indexes such as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). Chronic inflammation is one of the major components of many autoimmune diseases and RDW may reflect the severity of these autoimmune diseases as well. Therefore, the objective of this study was to investigate the correlation between RDW and disease activity of systemic lupus erythematosus (SLE).
METHODS
The medical records of 131 SLE patients were retrospectively analyzed. Correlations between RDW and disease activity or other inflammatory indexes were analyzed. The effect of glucocorticoid treatment for three months on RDW was estimated in 3 newly diagnosed SLE cases.
RESULTS
Increased RDW was observed in SLE patients. RDW was positively correlated with serum IgM, CRP, ESR, and SLE Disease Activity Index 2000 (SLEDAI-2K). Glucocorticoid treatment decreased both SLEDAI-2K and RDW.
CONCLUSION
RDW may be a useful index to estimate the disease activity of SLE.
背景
基于普通人群的调查显示，红细胞分布宽度（RDW）与红细胞沉降率（ESR）和 C 反应蛋白（CRP）等炎症指标相关。慢性炎症是许多自身免疫性疾病的主要组成部分之一，RDW 可能也反映了这些自身免疫性疾病的严重程度。因此，本研究旨在探讨 RDW 与系统性红斑狼疮（SLE）疾病活动度之间的相关性。
方法
回顾性分析了 131 例 SLE 患者的病历。分析了 RDW 与疾病活动度或其他炎症指标之间的相关性。在 3 例新诊断的 SLE 患者中，评估了糖皮质激素治疗 3 个月对 RDW 的影响。
结果
SLE 患者的 RDW 升高。RDW 与血清 IgM、CRP、ESR 和系统性红斑狼疮疾病活动度 2000 评分（SLEDAI-2K）呈正相关。糖皮质激素治疗降低了 SLEDAI-2K 和 RDW。
结论
RDW 可能是评估 SLE 疾病活动度的有用指标。
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