University of Lille Nord de France, CHU Lille, Lille, France.
Stroke. 2013 Aug;44(8):2324-6. doi: 10.1161/STROKEAHA.113.001355. Epub 2013 May 16.
We tested the hypothesis that excessive chronic ethanol consumption is associated with more severe ischemic strokes.
We recruited patients with supratentorial cerebral ischemia within 48 hours of symptom onset. We defined heavy drinkers by a weekly consumption of ethanol of ≥300 g and severe strokes by a National Institutes of Health Stroke Scale score≥6.
Of 436 patients, 60 were heavy drinkers. Being a heavy drinker was independently associated with baseline National Institutes of Health Stroke Scale scores≥6 (odds ratio, 2.35; 95% confidence interval, 1.12-5.26; P=0.023) at the logistic regression analysis. This result was not modified with the propensity analysis.
An excessive chronic ethanol consumption is associated with higher baseline stroke severity.
我们检验了以下假说，即过度的慢性乙醇摄入与更严重的缺血性脑卒中相关。
我们招募了症状发作后 48 小时内出现幕上脑缺血的患者。我们将每周乙醇摄入量≥300g 的患者定义为重度饮酒者，将 NIHSS 评分≥6 的患者定义为重度脑卒中患者。
在 436 名患者中，有 60 名是重度饮酒者。在逻辑回归分析中，重度饮酒与基线 NIHSS 评分≥6（比值比，2.35；95%置信区间，1.12-5.26；P=0.023）独立相关。该结果在倾向评分分析中未发生改变。
慢性乙醇摄入过度与更高的基线脑卒中严重程度相关。
