纳米二次离子质谱多元素成像揭示了一种带高电荷多核铂化合物的内化和核仁靶向作用。
NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound.
机构信息
Institute for Glycomics, Griffith University, Gold Coast Campus, QLD 4222, Australia.
出版信息
Chem Commun (Camb). 2013 Aug 11;49(62):6944-6. doi: 10.1039/c3cc42098a.
Abstract
Simultaneous multi-element imaging using NanoSIMS (nano-scale secondary ion mass spectrometry), exploiting the novel combination of (195)Pt and (15)N in platinum-am(m)ine antitumour drugs, provides information on the internalisation and subcellular localisation of both metal and ligands, and allows identification of ligand exchange.
摘要
利用 NanoSIMS（纳米级二次离子质谱）进行同时多元素成像，利用铂-氨（am）类抗肿瘤药物中（195）Pt 和（15）N 的新颖组合，提供了关于金属和配体的内化和亚细胞定位的信息，并允许识别配体交换。
相似文献
1
NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound.纳米二次离子质谱多元素成像揭示了一种带高电荷多核铂化合物的内化和核仁靶向作用。
Chem Commun (Camb). 2013 Aug 11;49(62):6944-6. doi: 10.1039/c3cc42098a.
2
Monofunctional platinum(ii) anticancer complexes based on multidentate phenanthridine-containing ligand frameworks.基于含菲啶多齿配体框架的单功能铂(ii)抗癌配合物。
Dalton Trans. 2020 May 26;49(20):6557-6560. doi: 10.1039/d0dt01275k.
3
Synthesis, spectroscopic and biological studies of a fluorescent Pt(II) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent.基于荧光 Pt(II)（三联吡啶）的 1,8-萘酰亚胺共轭物作为 DNA 靶向剂的合成、光谱和生物学研究。
Chem Commun (Camb). 2013 Oct 4;49(76):8522-4. doi: 10.1039/c3cc44962a.
4
Novel clioquinol and its analogous platinum complexes: importance, role of the halogen substitution and the hydroxyl group of the ligand.新型氯碘羟喹及其类似物铂配合物：重要性、卤代取代和配体羟基的作用。
Dalton Trans. 2013 Oct 7;42(37):13343-8. doi: 10.1039/c3dt51720a. Epub 2013 Aug 14.
5
Synthesis, characterization and biological investigation of platinum(ii) complexes with asparagusic acid derivatives as ligands.以天门冬氨酸衍生物为配体的铂（II）配合物的合成、表征及生物学研究。
Dalton Trans. 2019 Jan 15;48(3):936-944. doi: 10.1039/c8dt02553c.
6
Enhanced Cytotoxicity and Reactivity of a Novel Platinum(IV) Family with DNA-Targeting Naphthalimide Ligands.一种新型含靶向DNA萘酰亚胺配体的铂（IV）家族的增强细胞毒性和反应活性
Inorg Chem. 2017 Jun 5;56(11):6175-6183. doi: 10.1021/acs.inorgchem.7b00136. Epub 2017 May 10.
7
Quinoxaline-2-carboxamide as a carrier ligand in two new platinum(II) compounds: Synthesis, crystal structure, cytotoxic activity and DNA interaction.喹喔啉-2-甲酰胺作为两种新型铂（II）化合物中的载体配体：合成、晶体结构、细胞毒性活性及与DNA的相互作用
Dalton Trans. 2010 Jun 7;39(21):5152-8. doi: 10.1039/c001158d.
8
Target-selective delivery and activation of platinum-based anticancer agents.铂基抗癌药物的靶向选择性递送与激活
Future Med Chem. 2015;7(7):911-27. doi: 10.4155/fmc.15.37.
9
The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex trans-[Pt(NH)(phenanthridine)Cl]NO.几何异构对单功能铂配合物反式-[Pt(NH)(菲啶)Cl]NO抗癌活性的影响。
Chem Commun (Camb). 2018 Mar 13;54(22):2788-2791. doi: 10.1039/c8cc00393a.
10
On the stability and biological behavior of cyclometallated Pt(IV) complexes with halido and aryl ligands in the axial positions.轴向位置带有卤代和芳基配体的环金属化铂（IV）配合物的稳定性和生物学行为
Bioorg Med Chem. 2016 Nov 15;24(22):5804-5815. doi: 10.1016/j.bmc.2016.09.037. Epub 2016 Sep 15.
引用本文的文献
1
A trackable trinuclear platinum complex for breast cancer treatment.一种用于乳腺癌治疗的可追踪三核铂配合物。
Nucleic Acids Res. 2025 Jul 8;53(13). doi: 10.1093/nar/gkaf628.
2
Modern Bioimaging Techniques for Elemental Tissue Analysis: Key Parameters, Challenges and Medical Impact.用于元素组织分析的现代生物成像技术：关键参数、挑战及医学影响
Molecules. 2025 Jul 5;30(13):2864. doi: 10.3390/molecules30132864.
3
Nano-scale imaging of dual stable isotope labeled oxaliplatin in human colon cancer cells reveals the nucleolus as a putative node for therapeutic effect.双稳定同位素标记的奥沙利铂在人结肠癌细胞中的纳米级成像揭示核仁是治疗作用的一个假定节点。
Nanoscale Adv. 2020 Nov 26;3(1):249-262. doi: 10.1039/d0na00685h. eCollection 2021 Jan 7.
4
NanoSIMS combined with fluorescence microscopy as a tool for subcellular imaging of isotopically labeled platinum-based anticancer drugs.纳米二次离子质谱联用荧光显微镜作为对同位素标记的铂类抗癌药物进行亚细胞成像的工具。
Chem Sci. 2014 Jun 6;5(8):3135-3143. doi: 10.1039/c3sc53426j. eCollection 2014 Jun 30.
5
Albumin-targeting of an oxaliplatin-releasing platinum(iv) prodrug results in pronounced anticancer activity due to endocytotic drug uptake .一种释放奥沙利铂的铂（IV）前药靶向白蛋白，由于通过内吞作用摄取药物，从而产生显著的抗癌活性。
Chem Sci. 2021 Aug 26;12(38):12587-12599. doi: 10.1039/d1sc03311e. eCollection 2021 Oct 6.
6
Subcellular Mass Spectrometry Imaging and Absolute Quantitative Analysis across Organelles.亚细胞质谱成像与细胞器的绝对定量分析。
ACS Nano. 2020 Apr 28;14(4):4316-4325. doi: 10.1021/acsnano.9b09804. Epub 2020 Apr 8.
7
Deciphering Metabolic Heterogeneity by Single-Cell Analysis.单细胞分析解析代谢异质性。
Anal Chem. 2019 Nov 5;91(21):13314-13323. doi: 10.1021/acs.analchem.9b02410. Epub 2019 Oct 8.
8
Tissue Imaging by Mass Spectrometry: A Practical Guide for the Medicinal Chemist.质谱组织成像：药物化学家实用指南
ACS Med Chem Lett. 2019 Jan 11;10(2):161-167. doi: 10.1021/acsmedchemlett.8b00480. eCollection 2019 Feb 14.
9
Boron-Containing Probes for Non-optical High-Resolution Imaging of Biological Samples.用于生物样品非光学高分辨率成像的含硼探针。
Angew Chem Int Ed Engl. 2019 Mar 11;58(11):3438-3443. doi: 10.1002/anie.201812032. Epub 2019 Feb 6.
10
Tumor Retention of Enzyme-Responsive Pt(II) Drug-Loaded Nanoparticles Imaged by Nanoscale Secondary Ion Mass Spectrometry and Fluorescence Microscopy.通过纳米二次离子质谱和荧光显微镜成像观察酶响应性负载铂（II）药物纳米颗粒在肿瘤中的滞留情况
ACS Cent Sci. 2018 Nov 28;4(11):1477-1484. doi: 10.1021/acscentsci.8b00444. Epub 2018 Oct 23.
本文引用的文献
1
Modulation of Ligand Fluorescence by the Pt(II)/Pt(IV) Redox Couple.Pt(II)/Pt(IV)氧化还原对调控配体荧光
Inorganica Chim Acta. 2012 Jul 1;389:77-84. doi: 10.1016/j.ica.2011.12.034. Epub 2012 Jan 3.
2
Heparan sulfate proteoglycan-mediated entry pathway for charged tri-platinum compounds: differential cellular accumulation mechanisms for platinum.硫酸乙酰肝素蛋白聚糖介导的带电荷三铂化合物进入途径：铂的细胞内积累机制差异。
Mol Pharm. 2012 Jun 4;9(6):1795-802. doi: 10.1021/mp300098t. Epub 2012 May 2.
3
Visualising gold inside tumour cells following treatment with an antitumour gold(I) complex.治疗后肿瘤细胞内金的可视化。
Metallomics. 2011 Sep;3(9):917-25. doi: 10.1039/c1mt00053e. Epub 2011 Jul 28.
4
Effects of noncovalent platinum drug-protein interactions on drug efficacy: use of fluorescent conjugates as probes for drug metabolism.非共价铂类药物-蛋白质相互作用对药物疗效的影响：荧光缀合物作为药物代谢探针的应用。
Mol Pharm. 2011 Jun 6;8(3):940-8. doi: 10.1021/mp2000583. Epub 2011 May 16.
5
Quantitative imaging of chemical composition in single cells by secondary ion mass spectrometry: cisplatin affects calcium stores in renal epithelial cells.通过二次离子质谱对单细胞化学成分进行定量成像：顺铂影响肾上皮细胞中的钙储备。
Methods Mol Biol. 2010;656:113-30. doi: 10.1007/978-1-60761-746-4_6.
6
Copper transporters and the cellular pharmacology of the platinum-containing cancer drugs.铜转运蛋白与含铂类抗癌药物的细胞药理学。
Mol Pharmacol. 2010 Jun;77(6):887-94. doi: 10.1124/mol.109.063172. Epub 2010 Feb 16.
7
Cellular imaging with secondary ion mass spectrometry.用二次离子质谱进行细胞成像。
Analyst. 2009 Nov;134(11):2204-15. doi: 10.1039/b913575h. Epub 2009 Sep 24.
8
Targeted delivery of chemotherapeutic agents using improved radiosensitive liquid core microcapsules and assessment of their antitumor effect.使用改良的放射敏感型液芯微胶囊靶向递送化疗药物及其抗肿瘤效果评估。
Int J Radiat Oncol Biol Phys. 2009 Oct 1;75(2):455-62. doi: 10.1016/j.ijrobp.2009.02.082.
9
Cytotoxic activities, cellular uptake, gene regulation, and optical imaging of novel platinum(II) complexes.新型铂（II）配合物的细胞毒性、细胞摄取、基因调控和光学成像。
Chem Res Toxicol. 2009 Oct;22(10):1705-12. doi: 10.1021/tx900180v.
10
Fluorescent analogues of quinoline reveal amine ligand loss from cis and trans platinum(II) complexes in cancer cells.喹啉的荧光类似物揭示了癌细胞中顺式和反式铂（II）配合物的胺配体损失。
J Inorg Biochem. 2009 Aug;103(8):1120-5. doi: 10.1016/j.jinorgbio.2009.05.005. Epub 2009 May 21.
Zotero 插件