纳米二次离子质谱多元素成像揭示了一种带高电荷多核铂化合物的内化和核仁靶向作用。
NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound.
机构信息
Institute for Glycomics, Griffith University, Gold Coast Campus, QLD 4222, Australia.
出版信息
Chem Commun (Camb). 2013 Aug 11;49(62):6944-6. doi: 10.1039/c3cc42098a.
Abstract
Simultaneous multi-element imaging using NanoSIMS (nano-scale secondary ion mass spectrometry), exploiting the novel combination of (195)Pt and (15)N in platinum-am(m)ine antitumour drugs, provides information on the internalisation and subcellular localisation of both metal and ligands, and allows identification of ligand exchange.
摘要
利用 NanoSIMS（纳米级二次离子质谱）进行同时多元素成像，利用铂-氨（am）类抗肿瘤药物中（195）Pt 和（15）N 的新颖组合，提供了关于金属和配体的内化和亚细胞定位的信息，并允许识别配体交换。
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