Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Parkville, VIC 3050, Australia.
J Clin Neurosci. 2013 Jul;20(7):907-11. doi: 10.1016/j.jocn.2013.03.006. Epub 2013 May 17.
Glioblastoma multiforme (GBM) is the most common brain tumor and has the worst prognosis. Several signaling molecules have been clearly implicated in the development, progression, and aggressiveness of GBM. Here we review the role of signal transducer and activator of transcription-3 (Stat3) in GBM. We particularly focus on its expression in clinical GBM samples, its role in brain tumorigenicity in cell lines and animal models, and discuss possible therapeutic strategies targeting Stat3. This review also summarizes the current knowledge regarding the role of Stat3 regulation by upstream activators and repressors in promoting GBM progression in both translational and clinical studies.
胶质母细胞瘤（GBM）是最常见的脑肿瘤，预后最差。有几种信号分子已明确参与 GBM 的发生、发展和侵袭。本文综述信号转导和转录激活因子 3（Stat3）在 GBM 中的作用。我们特别关注其在临床 GBM 样本中的表达、在细胞系和动物模型中的脑肿瘤发生作用，并讨论针对 Stat3 的可能治疗策略。本文还总结了目前关于 Stat3 上游激活剂和抑制剂在促进 GBM 进展方面的调节作用的知识，包括转化和临床研究。
