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甲苯滥用与脑白质:一种中毒性脑白质病模型。

Toluene abuse and white matter: a model of toxic leukoencephalopathy.

机构信息

Behavioral Neurology Section, University of Colorado School of Medicine, 12631 East 17th Avenue, MS B185, Aurora, CO 80045, USA.

出版信息

Psychiatr Clin North Am. 2013 Jun;36(2):293-302. doi: 10.1016/j.psc.2013.02.008. Epub 2013 Apr 15.

DOI:10.1016/j.psc.2013.02.008
PMID:23688693
Abstract

The brain is the primary target of toluene (methylbenzene), the major solvent in spray paint and a constituent of many other easily obtained commercial and industrial products. The effects of acute intoxication can be dramatic and the lasting adverse effects of inhalants may be highly injurious. Mental status alterations range from acute confusional state to coma. Toluene abuse effects on white matter are demonstrable neuroradiologically and neuropathologically, and have important neurobehavioral consequences.

摘要

大脑是甲苯(甲基苯)的主要靶器官,甲苯是喷漆的主要溶剂,也是许多其他容易获得的商业和工业产品的成分。急性中毒的影响可能非常显著,吸入剂的持久不良反应可能是高度有害的。精神状态改变范围从急性意识混乱到昏迷。甲苯滥用对白质的影响在神经影像学和神经病理学上都有显示,并有重要的神经行为后果。

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