Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, United States.
Curr Opin Immunol. 2013 Jun;25(3):366-72. doi: 10.1016/j.coi.2013.04.003. Epub 2013 May 18.
Our bodies are continuously exposed to various types of infectious pathogens. Vaccinations are the most cost effective way to protect our bodies against a variety of infectious microbes. The efficacy of most vaccines relies on protective antibody production and generation of memory B cells. These two key components develop mostly from B cells that participate in germinal center reactions. Recent efforts have highlighted the critical role of follicular helper CD4 T (Tfh) cells in the generation of germinal centers. Given that Bcl6 is a major transcription factor for Tfh differentiation, here we review recent developments in the understanding of signaling molecules that regulate Bcl6 expression in CD4 T cells, as a potential target for development of more efficacious vaccines.
我们的身体不断受到各种类型的感染性病原体的侵袭。接种疫苗是保护身体免受各种传染性微生物侵害的最具成本效益的方法。大多数疫苗的功效依赖于保护性抗体的产生和记忆 B 细胞的生成。这两个关键组成部分主要来自参与生发中心反应的 B 细胞。最近的研究强调了滤泡辅助性 CD4 T（Tfh）细胞在生发中心生成中的关键作用。鉴于 Bcl6 是 Tfh 分化的主要转录因子，我们在这里综述了调节 CD4 T 细胞中 Bcl6 表达的信号分子的最新研究进展，这可能是开发更有效的疫苗的一个潜在靶点。
