Kastrissios H, Triggs E J, Mogg G A, Sainsbury D, Higbie J, Leow K, Sidhu J
Queen Elizabeth II Jubilee Hospital, Brisbane, Queensland.
Anaesth Intensive Care. 1990 May;18(2):200-4. doi: 10.1177/0310057X9001800207.
Venous plasma concentrations of bupivacaine were determined in eight cholecystectomy patients following multiple interpleural bolus instillations of bupivacaine 20 ml 0.5% with adrenaline (5 mg/l) administered at six- to eight-hour intervals. The mean steady-state peak plasma concentration was 2.3 mg/l (range 1.2-3.1 mg/l); however, in three of the eight patients peak plasma concentrations were greater than 3 mg/l. The mean accumulation ratio was found to be 1.6 (range 0.99-2.49), with steady-state occurring within the first 24 hours of drug administration. Mean apparent systemic plasma clearance was 0.16 +/- 0.07 l/kg/h with a mean terminal half-life of 5.8 +/- 2.3 hours measured at steady-state, values which were not significantly different (P greater than 0.05) from those values obtained following single interpleural bolus dose administration.
在八名接受胆囊切除术的患者中，测定了布比卡因的静脉血浆浓度。这些患者每隔六至八小时接受多次胸膜间大剂量注射20毫升0.5%布比卡因加肾上腺素（5毫克/升）。平均稳态血浆峰值浓度为2.3毫克/升（范围为1.2至3.1毫克/升）；然而，在八名患者中有三名患者的血浆峰值浓度大于3毫克/升。发现平均蓄积比为1.6（范围为0.99至2.49），在给药的头24小时内达到稳态。平均表观全身血浆清除率为0.16±0.07升/千克/小时，在稳态下测得的平均终末半衰期为5.8±2.3小时，这些值与单次胸膜间大剂量给药后获得的值无显著差异（P大于0.05）。
