Mogg G A, Triggs E J, Ismail Z, Higbie J, Frost M
Department of Surgery, Queen Elizabeth II Jubilee Hospital, Coopers Plains Q, Australia.
Br J Anaesth. 1990 Jun;64(6):657-61. doi: 10.1093/bja/64.6.657.
Arterial and venous plasma concentrations of bupivacaine were measured following interpleural administration of 20 ml of 0.5% solution with adrenaline in patients undergoing cholecystectomy. Mean maximum arterial and venous concentrations in eight of 11 patients were 1.90 (SD 0.36) and 1.65 (0.48) mg litre-1 and occurred at 22 (10) min and 25 (10) min, respectively. An arteriovenous difference for bupivacaine of approximately 20% was noted during the first 45-60 min after administration. Mean systemic venous plasma clearance (0.15 (0.08) litre h-1 kg-1) was less and the mean elimination half-life (6.85 (2.29) h) and mean body residence time (9.99 (3.00) h) were longer than reported previously for interpleural bupivacaine--possibly because of continued slow absorption of the drug from its absorption site.
在接受胆囊切除术的患者中，于胸膜间给予20毫升含肾上腺素的0.5%布比卡因溶液后，测定动脉和静脉血浆中的布比卡因浓度。11例患者中有8例的平均动脉和静脉最大浓度分别为1.90（标准差0.36）和1.65（0.48）毫克/升，分别在22（10）分钟和25（10）分钟时出现。给药后最初45 - 60分钟内，布比卡因的动静脉差异约为20%。平均全身静脉血浆清除率（0.15（0.08）升/小时·千克-1）较低，平均消除半衰期（6.85（2.29）小时）和平均体内驻留时间（9.99（3.00）小时）比先前报道的胸膜间布比卡因情况更长——这可能是由于药物从吸收部位持续缓慢吸收所致。
