Haghighi Anousheh, Samimagham Hamidreza, Gohardehi Golnar
Division of Rheumatology, Tehran University of Medical Sciences, Tehran, Iran.
Iran J Kidney Dis. 2013 May 21;7(3):210-3.
Calcium and vitamin D are essential structural components of the skeletal system, which prevent osteoporosis after menopause. However, there is a controversial debate on the association between the intake of calcium and vitamin D supplements and the increased risk of formation of kidney calculi in postmenopausal women. which yet have to be confirmed. This study aimed to compare the metabolic changes after supplementation of calcium and vitamin D and examine the risk of stone formation.
Fifty-three postmenopausal women referred to rheumatology clinic who had no history of kidney calculi, bone diseases (apart from osteoporosis), metabolic, and rheumatic disorders and had not been receiving calcium, diuretics and calcitonin were investigated. Renal ultrasonography and blood tests were performed and the urine calcium levels were measured for a period of 24 hours for all patients. The examinations were repeated after a 1- year period of treatment with supplemental calcium (100 mg/d) and vitamin D (400 IU/d) and compared with the data before the treatment.
After 1 year, asymptomatic lithiasis was confirmed in 1 of 53 patients (1.9%) using ultrasonographic examination. No significant differences were found between the 24-hour urine and blood calcium levels before and after the treatment.
Our findings showed that oral intake of calcium and vitamin D after 1 year has no effect on the urinary calcium excretion rate and the formation of kidney calculi in postmenopausal women.
钙和维生素D是骨骼系统的重要结构组成部分，可预防绝经后骨质疏松症。然而，关于绝经后女性补充钙和维生素D与肾结石形成风险增加之间的关联存在争议，尚待证实。本研究旨在比较补充钙和维生素D后的代谢变化，并检查结石形成风险。
对53名转诊至风湿病诊所的绝经后女性进行了调查，这些女性无肾结石病史、骨病（除骨质疏松症外）、代谢性疾病和风湿性疾病，且未接受过钙、利尿剂和降钙素治疗。对所有患者进行了肾脏超声检查和血液检测，并测量了24小时尿钙水平。在补充钙（100mg/d）和维生素D（400IU/d）治疗1年后重复进行检查，并与治疗前的数据进行比较。
1年后，通过超声检查在53名患者中的1名（1.9%）确诊为无症状结石。治疗前后24小时尿钙和血钙水平无显著差异。
我们的研究结果表明，绝经后女性口服钙和维生素D 1年后对尿钙排泄率和肾结石形成无影响。
