School of Medicine, Catholic University of the Sacred Heart, Rome, Italy.
Eur Rev Med Pharmacol Sci. 2013 May;17(9):1167-73.
The mechanisms underlying bowel disturbances in coeliac disease are still relatively unclear. Past reports suggested that small bowel motor abnormalities may be involved in this pathological condition; there are no studies addressing small bowel transit in coeliac disease before and after a gluten-free diet.
The objective of this study was to determine whether capsule endoscopy (CE) could serve as a test for measurement of gastric and small bowel transit times in a group of symptomatic or asymptomatic coeliac patients at the time of diagnosis with respect to a control group.
Thirty coeliac untreated patients and 30 age-, sex- and BMI-matched healthy controls underwent CE assessment of whole gut transit times.
All subjects completed the study per protocol and experienced natural passage of the pill. No statistical significant differences between gastric emptying and small bowel transit times both in coeliac and control group were found (p = 0.1842 and p = 0.7134; C.I. 95%, respectively). No correlation was found in coeliac patients and control group between transit times and age, sex and BMI. By using the Pearson's correlation test, significant correlation emerged between gastric emptying time and small bowel transit times in coeliac disease (r = 0.1706).
CE reveals unrecognized gender differences and may be a novel outpatient technique for gut transit times' assessment without exposure to radiation and for the evaluation of upper gut dysfunction in healthy patients suffering from constipation without evidence of intestinal malabsorption. Nevertheless, CE does not seem to be the most suitable method for studying gut transit times in untreated coeliac patients; this might be ascribed to the fact that CE consists of inert (non-digestible, non-absorbable) substances.
乳糜泻中肠道紊乱的机制仍相对不清楚。过去的报告表明，小肠运动异常可能与这种病理状况有关；尚未有研究在乳糜泻患者进行无麸质饮食前后探讨小肠转运。
本研究旨在确定胶囊内镜（CE）是否可作为一种检测方法，用于测量一组有症状或无症状乳糜泻患者在诊断时相对于对照组的胃和小肠转运时间。
30 例未经治疗的乳糜泻患者和 30 名年龄、性别和 BMI 匹配的健康对照者接受了整个肠道转运时间的 CE 评估。
所有患者均按方案完成研究并经历了药丸的自然排出。在乳糜泻和对照组中，胃排空和小肠转运时间均无统计学差异（p = 0.1842 和 p = 0.7134；95%CI）。在乳糜泻患者和对照组中，转运时间与年龄、性别和 BMI 之间均无相关性。在乳糜泻患者中，通过 Pearson 相关检验发现胃排空时间与小肠转运时间之间存在显著相关性（r = 0.1706）。
CE 揭示了未被认识的性别差异，并且可能是一种新颖的门诊技术，用于评估健康患者的肠道转运时间，而无需暴露于辐射，并且用于评估患有便秘而无肠道吸收不良证据的健康患者的上消化道功能障碍。然而，CE 似乎不是研究未经治疗的乳糜泻患者肠道转运时间的最适宜方法；这可能归因于 CE 由惰性（不可消化、不可吸收）物质组成。
