Retinoblastoma after 15 years.

Retinoblastoma, a cancer of early childhood, occurs once in 18,000 to 30,000 live births worldwide. Not only are bilateral cases diagnosed at an earlier age than unilateral cases, but bilateral cases are also associated with multifocal tumors. A ten-month-old girl was treated for bilateral retinoblastoma (the right eye was Group Ia; the left eye was Group IIIb) with 3500 rads of external beam radiation. The metastatic workup was negative. Because new tumors developed OS, a combination of photocoagulation and cryotherapy treatments were necessary. Fifteen years after treatment, the right eye had Type II regression and the left eye, Type III.