Igbinosa Etinosa O, Odjadjare Emmanuel E, Chigor Vincent N, Igbinosa Isoken H, Emoghene Alexander O, Ekhaise Fredrick O, Igiehon Nicholas O, Idemudia Omoruyi G
Department of Microbiology, Faculty of Life Sciences, University of Benin, PMB 1154, Benin City, Nigeria.
ScientificWorldJournal. 2013 Apr 3;2013:460215. doi: 10.1155/2013/460215. Print 2013.
Chlorophenol compounds and their derivatives are ubiquitous contaminants in the environment. These compounds are used as intermediates in manufacturing agricultural chemicals, pharmaceuticals, biocides, and dyes. Chlorophenols gets into the environment from a variety of sources such as industrial waste, pesticides, and insecticides, or by degradation of complex chlorinated hydrocarbons. Thermal and chemical degradation of chlorophenols leads to the formation of harmful substances which constitute public health problems. These compounds may cause histopathological alterations, genotoxicity, mutagenicity, and carcinogenicity amongst other abnormalities in humans and animals. Furthermore, the recalcitrant nature of chlorophenolic compounds to degradation constitutes an environmental nuisance, and a good understanding of the fate and transport of these compounds and their derivatives is needed for a clearer view of the associated risks and mechanisms of pathogenicity to humans and animals. This review looks at chlorophenols and their derivatives, explores current research on their effects on public health, and proffers measures for mitigation.
氯酚化合物及其衍生物是环境中普遍存在的污染物。这些化合物被用作制造农用化学品、药品、杀虫剂和染料的中间体。氯酚通过多种来源进入环境，如工业废物、农药和杀虫剂，或通过复杂氯代烃的降解。氯酚的热降解和化学降解会导致有害物质的形成，从而构成公共卫生问题。这些化合物可能会导致人类和动物出现组织病理学改变、遗传毒性、致突变性和致癌性等异常情况。此外，氯酚类化合物难以降解的特性构成了环境公害，为了更清楚地了解这些化合物及其衍生物对人类和动物的相关风险和致病机制，需要深入了解它们的归宿和迁移情况。本综述着眼于氯酚及其衍生物，探讨了当前关于它们对公众健康影响的研究，并提出了缓解措施。
