Hishinuma K, Nishimura T, Konno A, Hashimoto Y, Kimura S
Laboratory of Nutrition, Faculty of Agriculture, Tohoku University, Sendai, Japan.
Ann Nutr Metab. 1990;34(2):76-84. doi: 10.1159/000177572.
Mice fed a 40% restricted diet until 1 year of age showed a 35% drop in body weight and markedly lower weights in the central lymphoid organs such as spleen and thymus than those of unrestricted mice. In contrast, the percentage of splenic Thy 1.2+ T cells was dramatically increased by dietary restriction. Splenic Ly 1+ T cells were also increased in the restricted mice. Spleen cells of the restricted mice revealed significantly higher responses not only in macrophage (MP)-dependent responses such as concanavalin A response and mixed-lymphocyte reaction but also in MP-independent T cell responses to recombinant interleukin 2 even at 1 year of age. These results strongly suggest that dietary restriction causes an enrichment of Thy 1.2+ T cells in spleen and augments the functions of T cells in mice.
喂食40%限制饮食直至1岁的小鼠体重下降了35%，与未限制饮食的小鼠相比，其脾脏和胸腺等中枢淋巴器官的重量明显更低。相比之下，饮食限制使脾脏中Thy 1.2+ T细胞的百分比显著增加。限制饮食的小鼠脾脏Ly 1+ T细胞也有所增加。即使在1岁时，限制饮食小鼠的脾细胞不仅在巨噬细胞（MP）依赖性反应如伴刀豆球蛋白A反应和混合淋巴细胞反应中表现出显著更高的反应，而且在对重组白细胞介素2的MP非依赖性T细胞反应中也表现出更高的反应。这些结果有力地表明，饮食限制导致脾脏中Thy 1.2+ T细胞富集，并增强了小鼠T细胞的功能。
