Karl T R, Sano S, Brawn W J, Mee R B
Victorian Pediatric Cardiac Surgical Unit, Royal Children's Hospital, Melbourne, Australia.
Ann Thorac Surg. 1990 Jul;50(1):105-9. doi: 10.1016/0003-4975(90)90099-r.
Between 1980 and 1989, 26 infants aged less than 1 month underwent open aortic valvotomy for critical aortic stenosis. All had congestive heart failure requiring inotropic agents (58%), ventilation (42%), and/or prostaglandin E1 (35%) preoperatively. Nine patients with isolated aortic stenosis had an operative mortality of 0%, whereas 17 patients with other anatomical lesions had a 47% mortality (p less than 0.01). Univariate analysis failed to identify additional risk factors other than year of operation (p less than 0.05). There were four late deaths, three probably related to arrhythmia (actuarial survival at 113 months = 0.53). Two patients have required late reoperation; neither required valve replacement.
1980年至1989年间,26名年龄小于1个月的婴儿因严重主动脉瓣狭窄接受了开放性主动脉瓣切开术。所有患儿术前均有充血性心力衰竭,需要使用正性肌力药物(58%)、通气支持(42%)和/或前列腺素E1(35%)。9例单纯主动脉瓣狭窄患者的手术死亡率为0%,而17例伴有其他解剖学病变的患者死亡率为47%(p<0.01)。单因素分析未能确定除手术年份外的其他危险因素(p<0.05)。有4例晚期死亡,3例可能与心律失常有关(113个月时的精算生存率=0.53)。2例患者需要晚期再次手术;均无需瓣膜置换。