Gory B, Bresson D, Rouchaud A, Yardin C, Mounayer C
Department of Interventional Neuroradiology, CHU Dupuytren, Limoges, France.
Interv Neuroradiol. 2013 Jun;19(2):147-52. doi: 10.1177/159101991301900201. Epub 2013 May 21.
Few animal models have been reported to evaluate and compare mechanical endovascular thrombectomy (MET) devices used to treat human ischemic stroke. These models may contribute to the understanding of arterial injury induced by a MET device and potentially by extrapolation to human intracranial arteries. We have developed a novel swine model for MET that allows visualization of the thrombus/device interaction and characterization of mechanical impact on the vessel wall. Twenty superficial femoral arteries were occluded with radiopaque thrombus, and 20 without thrombus were treated with thrombectomy devices. Acute histopathological changes were evaluated. The swine femoral artery, which is comparable in size to the human middle cerebral artery or basilar artery, may offer a useful animal model for the study of histologic alterations induced by MET.
据报道，很少有动物模型用于评估和比较用于治疗人类缺血性中风的机械性血管内血栓切除术（MET）设备。这些模型可能有助于理解MET设备引起的动脉损伤，并有可能通过类推来了解人类颅内动脉的情况。我们开发了一种用于MET的新型猪模型，该模型可以可视化血栓/设备相互作用，并对血管壁的机械影响进行表征。20条股浅动脉用不透射线的血栓闭塞，另外20条没有血栓的股浅动脉用血栓切除术设备进行治疗。评估急性组织病理学变化。猪的股动脉在大小上与人类大脑中动脉或基底动脉相当，可能为研究MET引起的组织学改变提供一个有用的动物模型。
