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[钙过敏、肾衰竭与痛风。一名高尿酸血症患者,高尿酸血症作为死亡风险因素]

[Calciphylaxis, renal failure and gout. A patient with hyperuricemia as a risk factor for death].

作者信息

Martínez-Martínez Marco Ulises, Román-Acosta Susana, Alvarez-Reyes Juan Manuel, Oros-Ovalle Cuauhtémoc, Abud-Mendoza Carlos

机构信息

Departamento de Medicina Interna, Hospital General de Zona 1, Instituto Mexicano del Seguro Social, San Luis Potosí, San Luis Potosí, México.

出版信息

Rev Med Inst Mex Seguro Soc. 2013 Mar-Apr;51(2):218-21.

PMID:23693113
Abstract

BACKGROUND

gout is an inflammatory arthritis that frequently is associated with obesity, alcohol consumption, hypertension and hypertriglyceridemia. The calciphylaxis is characterized by metastatic calcification to small and medium vessels. Both are associated independently with high mortality. When hyperuricemia and the calciphylaxis are present, the death risk is 80 %.

CLINICAL CASE

a 51 year old man presented with clinical history of alcoholism and systemic arterial hypertension, and he developed limb ulcers, edema and uremic syndrome. Three week later, the patient died as a consequence of sepsis from Staphylococcus aureus. We emphasize the diagnostic approach of calciphylaxis, metabolic syndrome and comorbidities, cardiovascular and renal failure risk factors.

CONCLUSIONS

the hyperuricemia is included in the metabolic syndrome, as the result of genetic and behavioral factors. It is recognized as a cardiovascular risk. For this reason we must consider it in the clinical practice guidelines for the prevention and treatment of diseases with high mortality.

摘要

背景

痛风是一种炎症性关节炎,常与肥胖、饮酒、高血压和高甘油三酯血症相关。钙沉着症的特征是中小血管转移性钙化。两者均独立与高死亡率相关。当存在高尿酸血症和钙沉着症时,死亡风险为80%。

临床病例

一名51岁男性,有酗酒和系统性动脉高血压病史,出现肢体溃疡、水肿和尿毒症综合征。三周后,患者因金黄色葡萄球菌败血症死亡。我们强调了钙沉着症、代谢综合征和合并症、心血管和肾衰竭危险因素的诊断方法。

结论

高尿酸血症由于遗传和行为因素而被纳入代谢综合征。它被认为是一种心血管风险。因此,我们必须在高死亡率疾病的预防和治疗临床实践指南中予以考虑。

相似文献

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[Calciphylaxis, renal failure and gout. A patient with hyperuricemia as a risk factor for death].[钙过敏、肾衰竭与痛风。一名高尿酸血症患者,高尿酸血症作为死亡风险因素]
Rev Med Inst Mex Seguro Soc. 2013 Mar-Apr;51(2):218-21.
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Management of gout: a 57-year-old man with a history of podagra, hyperuricemia, and mild renal insufficiency.痛风的治疗:一位 57 岁男性,有痛风石病史、高尿酸血症和轻度肾功能不全。
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Inflammation: a possible mechanism for a causative role of hyperuricemia/gout in cardiovascular disease.炎症:高尿酸血症/痛风在心血管疾病中起致病作用的一种可能机制。
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[Gout as a systemic disease: systemic manifestations and comorbidities of hyperuricaemia].[作为一种全身性疾病的痛风:高尿酸血症的全身表现及合并症]
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Ulcerated tophaceous gout.溃疡性痛风石性痛风
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