Smirnova E A, Davydov M I, Polotskiĭ B E, Malaev S G
Arkh Patol. 1990;52(3):33-7.
The material of 70 patients with lung adenocarcinomas radically operated at the All-Union Cancer Research Centre is analyzed. The spread of tumour expressed in terms of TNM system (I group--T1-3 N0M0--37 patients, II group--T1-3 N1M0--18 patients, III group--T1-3 N2M0--11 patients, IV group--T1-3 N1M1--4 patients) and its ultrastructure served as criteria. The correlation is found between the life-span, degree and type of the tumour cell ultrastructural differentiation. The most favourable prognosis at comparable tumour spread is found when the tumour cell ultrastructural differentiation corresponded to that of Clara type, pneumocytes of II order and ciliary type. Less favourable ultrastructural features were the domination of undifferentiated cells and the presence of goblet cells and those having the signs of differentiation into the various directions. The lack of correlation of the differentiation at the light microscopic and ultrastructural levels is found in some cases this being reflected in delayed results.
对全苏癌症研究中心70例接受根治性手术的肺腺癌患者的材料进行了分析。以TNM系统（I组——T1 - 3 N0M0——37例患者，II组——T1 - 3 N1M0——18例患者，III组——T1 - 3 N2M0——11例患者，IV组——T1 - 3 N1M1——4例患者）表示的肿瘤扩散情况及其超微结构作为标准。发现肿瘤细胞超微结构分化的寿命、程度和类型之间存在相关性。当肿瘤细胞超微结构分化与克拉拉细胞型、II型肺上皮细胞和纤毛细胞型相对应时，在可比的肿瘤扩散情况下预后最有利。不太有利的超微结构特征是未分化细胞占主导以及存在杯状细胞和具有向不同方向分化迹象的细胞。在某些情况下，发现光镜和超微结构水平的分化缺乏相关性，这反映在结果延迟上。
