Perevoshchikov A G, Cherkes V L, Raĭkhlin N T, Knysh V I, Katenkamp D
Vopr Onkol. 1989;35(9):1053-8.
A retrospective study of the ultrastructure of rectal tumors in patients with favorable and unfavorable prognosis was undertaken. It established favorable postoperative course and prognosis in tumors containing more than half undifferentiated cells. Conversely, tumors in which malignant cells with electron microscopy-identifiable signs of differentiation (retaining features of normal cells) prevailed and those containing equal fractions of well- and poorly differentiated cells involve early development of metastasis and sometimes recurrences.
对预后良好和预后不良的直肠癌患者的超微结构进行了回顾性研究。研究发现，含有超过一半未分化细胞的肿瘤术后病程和预后良好。相反，恶性细胞具有电镜可识别的分化迹象（保留正常细胞特征）占优势的肿瘤，以及含有相等比例高分化和低分化细胞的肿瘤，往往早期发生转移，有时还会复发。
