[乍得结核病治疗中断相关因素评估]
[Evaluation of factors associated with tuberculosis treatment default in Chad].
作者信息
Ndeikoundam Ngangro N, Ngarhounoum D, Ngangro M N, Rangar N, Halley des Fontaines V, Chauvin P
机构信息
INSERM UMRS 707, Université Pierre et Marie Curie-Paris 6, UMRS 707, 27 rue Chaligny, Paris, France.
出版信息
Med Sante Trop. 2013 Jan-Mar;23(1):60-5. doi: 10.1684/mst.2013.0159.
INTRODUCTION
Tuberculosis (TB) treatment default contributes to the perpetuation of the epidemic and increases the risk of emergence of new forms of multidrug-resistant TB. The aim of this study was to identify the factors associated with treatment default in Chad.
METHOD
This prospective study interviewed 286 patients with pulmonary TB in three centers, recruited at the beginning of treatment. We compared patients who completed the treatment to the treatment defaulters. A logistic regression model was fit to identify factors associated with default.
RESULT
32% of patients defaulted, that is, abandoned treatment. The multivariate analysis demonstrated that a low educational level and ignorance of the contagious nature of TB were associated with treatment interruption.
CONCLUSION
TB education, patient assistance, and active tracing of patients who fail to return can help to prevent abandonment of TB treatment.
引言
结核病治疗中断致使该流行病持续存在，并增加了新型耐多药结核病出现的风险。本研究的目的是确定乍得与治疗中断相关的因素。
方法
这项前瞻性研究在三个中心对286例肺结核患者进行了访谈，这些患者在治疗开始时被招募。我们将完成治疗的患者与治疗中断者进行了比较。采用逻辑回归模型来确定与治疗中断相关的因素。
结果
32%的患者中断治疗，即放弃治疗。多变量分析表明，教育水平低以及对结核病传染性的无知与治疗中断有关。
结论
结核病教育、患者援助以及对未复诊患者的积极追踪有助于防止结核病治疗的中断。
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