East Mediterr Health J. 2013 Aug;19(8):687-93.
Interruption in tuberculosis (TB) treatment still remains the most important challenge for control of the disease. This study aimed to identify the determinants of TB treatment default in Fez, Morocco. A 1:2 pair-matched case-control study was carried out in the TB control units in Fez. Cases were defaulters to TB treatment and were matched by age and sex to non-defaulters (controls). Of the 320 patients (108 defaulters, 212 controls), 80.6% were male. The main reason for defaulting reported by patients was the sensation of being cured. Predictive factors for treatment default in the multivariate conditional logistic regression analysis, were: relapsed case (adjusted OR = 4.49; 95% Cl: 1.87-10.8), current smoking (aOR= 2.10; 95% Cl: 1.07-4.14), alcohol use (aOR = 2.92; 95% Cl: 1.04-8.19), being more than 30 minutes away from the health centre (aOR = 3.34; 95% Cl: 1.06-10.5) and perception of having received insufficient explanation about the disease (aOR = 2.87; 95% CI: 1.53-5.36). The rate of defaulting in Fez can be lowered through targeted and realistic measures.
结核病（TB）治疗中断仍然是控制该疾病的最重要挑战。本研究旨在确定摩洛哥非斯结核病治疗中断的决定因素。在非斯的结核病控制单位进行了 1:2 配对病例对照研究。病例是结核病治疗的违约者，并按年龄和性别与非违约者（对照）相匹配。在 320 名患者（108 名违约者，212 名对照者）中，80.6%为男性。患者违约的主要原因是感觉已治愈。多变量条件逻辑回归分析中治疗违约的预测因素包括：复发病例（调整后的 OR = 4.49；95% Cl：1.87-10.8）、当前吸烟（aOR = 2.10；95% Cl：1.07-4.14）、饮酒（aOR = 2.92；95% Cl：1.04-8.19）、距离卫生中心超过 30 分钟（aOR = 3.34；95% Cl：1.06-10.5）和对疾病接受的解释不足的感知（aOR = 2.87；95% CI：1.53-5.36）。通过有针对性和现实的措施，可以降低非斯的违约率。
