Retinal and Inflammatory Eye Disease, Centre for Ophthalmic Specialized Care (COS), Clinic Montchoisi, Lausanne, SwitzerlandDepartment of Ophthalmology, University Hospital Zurich, Zurich, SwitzerlandDepartment of Neurosciences, Eye Clinic, Ophthalmology and Genetics, University of Genova, Genova, ItalyUniversity of Lausanne, Lausanne, Switzerland.
Acta Ophthalmol. 2013 Nov;91(7):e550-5. doi: 10.1111/aos.12150. Epub 2013 May 22.
To analyse the indocyanine green angiography (ICGA) patterns of hypofluorescence that are compatible with choriocapillaritis that occur secondarily to toxoplasmic retinochoroiditis (ToRC), ocular tuberculosis (including tuberculous choroiditis, TuCR and multifocal serpiginoid choroiditis, TMSC) and syphilitic chorioretinitis (SyCR).
This was a single centre, retrospective case review study. Patients with a diagnosis of ToRC, TuCR, TMSC or SyCR were identified, their charts were reviewed and fundus photographs, fluorescein angiography (FA) and ICGA pictures were assessed.
Indocyanine green angiography was performed at the initial presentation in 63 of the 105 patients with ToRC, in 37 of the 38 patients with TuCR, in six of six patients with TMSC and in two of four patients with SyCR. The following four ICGA patterns indicated choriocapillaritis: extension of hypofluorescence beyond the hypofluorescence of the actual infectious focus as seen on fundus photography or FA (seen only in ToRC and TuCR); small dark dots around the infectious focus (seen only in ToRC); multiple 'confetti-like' hypofluorescent areas or hypofluorescent geographical confluent areas (seen only in TMSC); and widespread areas of nonperfusion visible only in ICGA (seen only in SyCR).
Patients with secondary choriocapillaritis have distinct typical ICGA findings. ICGA is thus an important diagnostic tool that can provide an explanation for otherwise obscure visual loss and that might have diagnostic value for specific conditions like ToRC and SyCR.
分析继发于弓形虫性视网膜炎脉络膜（ToRC）、眼结核（包括结核性脉络膜炎，TuCR 和多灶性匐行性脉络膜脉络膜炎，TMSC）和梅毒性视网膜炎脉络膜炎（SyCR）的脉络膜毛细血管炎的弱荧光吲哚菁绿血管造影（ICGA）模式。
这是一项单中心回顾性病例研究。确定了诊断为 ToRC、TuCR、TMSC 或 SyCR 的患者，回顾了他们的图表，并评估了眼底照片、荧光素血管造影（FA）和 ICGA 图像。
在 105 例 ToRC 患者中的 63 例、38 例 TuCR 患者中的 37 例、6 例 TMSC 患者中的 6 例和 4 例 SyCR 患者中的 2 例，在初次就诊时进行了吲哚菁绿血管造影。以下四种 ICGA 模式表明脉络膜毛细血管炎：在眼底摄影或 FA 上观察到的实际感染灶的弱荧光之外延伸的弱荧光（仅见于 ToRC 和 TuCR）；感染灶周围的小黑点（仅见于 ToRC）；多个“五彩纸屑样”弱荧光区或弱荧光地理融合区（仅见于 TMSC）；仅在 ICGA 中可见的广泛无灌注区（仅见于 SyCR）。
继发于脉络膜毛细血管炎的患者有明显的典型 ICGA 发现。因此，ICGA 是一种重要的诊断工具，可以为其他原因不明的视力丧失提供解释，并且可能对特定疾病（如 ToRC 和 SyCR）具有诊断价值。
