Park Jun Eun, Park Il Joong, Lim Young Ae, Lee Wee Gyo, Cho Sung Ran
Department of Pediatrics, Ajou University School of Medicine, Suwon, Republic of Korea.
Ann Clin Lab Sci. 2013 Spring;43(2):186-9.
Blasts showing hemophagocytosis have been very rarely reported in acute lymphoblastic leukemia. We report a pediatric case of B lymphoblastic leukemia (BLL) with t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1) showing erythrophagocytosis and thrombophagocytosis by leukemic blasts. About 4% of the leukemic blasts in marrow aspirate smears showed phagocytosis of erythrocytes, platelets, or nuclear remnants in a 3-year-old Korean boy with a diagnosis of BLL. Conventional cytogenetics and molecular analysis revealed the presence of t(12;21)(p13;q22); TEL-AML1 (ETV6-RUNX1). The patient responded well to chemotherapy and is in a state of complete remission.
急性淋巴细胞白血病中出现具有噬血细胞现象的原始细胞的报道极为罕见。我们报告一例患有t(12;21)(p13;q22); TEL-AML1（ETV6-RUNX1）的B淋巴细胞白血病（BLL）小儿病例，其白血病原始细胞表现出红细胞吞噬和血小板吞噬现象。在一名诊断为BLL的3岁韩国男孩的骨髓穿刺涂片样本中，约4%的白血病原始细胞表现出对红细胞、血小板或核残余物的吞噬作用。常规细胞遗传学和分子分析显示存在t(12;21)(p13;q22); TEL-AML1（ETV6-RUNX1）。该患者对化疗反应良好，目前处于完全缓解状态。
