Vandepitte K, Vanrenterghem Y, Michielsen P
Department of Nephrology, U.Z. Gasthuisberg, Leuven, Belgium.
Transpl Int. 1990 May;3(1):47-8. doi: 10.1007/BF00333203.
Hypersensitive reactions to azathioprine have been reported infrequently, and always in nontransplanted patients. Here, a renal transplant recipient with a severe hypersensitive reaction to azathioprine is described. We suggest that, until recently, hypersensitivity to azathioprine was suppressed in transplant recipients by the association of high doses of corticosteroids. Since the introduction of cyclosporin, azathioprine therapy is usually associated with corticosteroids in a much lower dose, so an increasing occurrence of azathioprine hypersensitivity in transplanted patients might be expected.
对硫唑嘌呤的过敏反应报道较少，且均发生于非移植患者。本文描述了1例对硫唑嘌呤发生严重过敏反应的肾移植受者。我们认为，直到最近，移植受者中对硫唑嘌呤的过敏反应因大剂量皮质类固醇的联合使用而受到抑制。自从引入环孢素以来，硫唑嘌呤治疗通常与低得多剂量的皮质类固醇联合使用，因此预计移植患者中硫唑嘌呤过敏反应的发生率会增加。
