Women's Headache Center, Department of Gynecology and Obstetrics, University of Turin, Via Ventimiglia 3, 10126 Turin, Italy.
Neurol Sci. 2013 May;34 Suppl 1(Suppl 1):S179-81. doi: 10.1007/s10072-013-1390-0.
At least 50 % of female migraineurs experience migraine associated with the perimenstrual period, even though they may also suffer from attacks at other times of the cycle (menstrually related migraine, MRM). MRM attacks tend to be longer and more intense than those arising in other phases of the menstrual cycle, and are often aggravated by more pronounced vegetative phenomena. In this open preliminary trial, we tested the efficacy of associating frovatriptan and dexketoprofen for the treatment of an acute attack of MRM, diagnosed according to the criteria of the International Headache Society, in 24 patients between 19 and 45 years of age (mean 31.33 ± 7.33). Twenty-one of them completed the study. Pain relief was achieved by 76 % of patients at 2 h and by 86 % at 4 h. A pain-free state was achieved by 48 % at 2 h and by 62 % at 4 h from taking the product. A pain-free state at 24 h was present in 76 % of MRM sufferers, 33 % of whom showed a sustained pain-free state at 24 h. A rescue medication was needed by eight patients. While decidedly encouraging, the data of this study obviously need confirmation with double blind studies involving a greater number of patients.
至少有 50%的女性偏头痛患者经历与经期相关的偏头痛，尽管她们也可能在月经周期的其他时间发作（与经期相关的偏头痛，MRM）。MRM 发作往往比其他月经周期阶段的发作持续时间更长、更剧烈，并且常常因更明显的植物性现象而加重。在这项开放的初步试验中，我们根据国际头痛协会的标准，测试了将氟曲普坦和右旋酮洛芬联合用于治疗 24 名 19 至 45 岁（平均 31.33 ± 7.33）女性偏头痛患者急性发作的疗效。其中 21 名患者完成了研究。76%的患者在 2 小时时缓解疼痛，86%的患者在 4 小时时缓解疼痛。48%的患者在 2 小时时达到无痛状态，62%的患者在 4 小时时达到无痛状态。76%的 MRM 患者在 24 小时时达到无痛状态，其中 33%的患者在 24 小时时保持无痛状态。有 8 名患者需要使用急救药物。虽然这些数据显然令人鼓舞，但显然需要用涉及更多患者的双盲研究来证实。
