Department of Neurology, Memory Disorders Unit, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Universitat AutŒnoma de Barcelona, Barcelona, Spain.
Am J Alzheimers Dis Other Demen. 2013 Aug;28(5):469-76. doi: 10.1177/1533317513488918. Epub 2013 May 21.
The aim of this study was to compare the applicability of the 1998 consensus diagnostic criteria for the behavioral variant of frontotemporal dementia (bvFTD) with the recently proposed diagnostic criteria of the International bvFTD Criteria Consortium (FTDC).
We reviewed each individual item in the 1998 and FTDC criteria in 30 patients with bvFTD followed in a memory clinic (including 2 with the C9orf72 gene repeat expansion).
All patients fulfilled the FTDC criteria (40% possible, 60% probable bvFTD) but only 66.7% fulfilled the 1998 criteria. One of the C9orf72 expansion carriers did not fulfill the 1998 criteria. This discordance was always due to the presence of exclusion features in the 1998 criteria, the most common being spatial disorientation and early severe amnesia.
The new FTDC criteria are less restrictive and hence more sensitive for the diagnosis of bvFTD.
本研究旨在比较行为变异额颞叶痴呆（bvFTD）的 1998 年共识诊断标准与最近提出的国际 bvFTD 标准制定联盟（FTDC）诊断标准的适用性。
我们回顾了在记忆门诊随访的 30 名 bvFTD 患者（包括 2 名 C9orf72 基因重复扩展患者）的 1998 年和 FTDC 标准中的每个单独项目。
所有患者均符合 FTDC 标准（40%可能，60%可能 bvFTD），但仅 66.7%符合 1998 年标准。C9orf72 基因重复扩展携带者之一不符合 1998 年标准。这种不相符总是由于 1998 年标准中的排除特征，最常见的是空间定向障碍和早期严重的健忘症。
新的 FTDC 标准的限制较少，因此对 bvFTD 的诊断更敏感。
