Department of Chemistry University of Auckland Private Bag 92019, Auckland, New Zealand.
Chemphyschem. 2000 Aug 4;1(1):60-2. doi: 10.1002/1439-7641(20000804)1:1<60::AID-CPHC60>3.0.CO;2-M.
The question is reopened, whether L- or D-alanine is more stable. Calculated parity-violating energy shifts for the 13 stable conformers of gaseous alanine (the picture shows the global minima) indicate that the stabilization of a certain enantiomer is strongly dependent on its conformation. Naturally occurring L-alanine is preferred for only seven of the investigated structures, which allows no definite conclusion on the relative stability of the two chiral forms to explain the origin of homochirality in living organisms.
这个问题再次被提出，究竟是 L-丙氨酸还是 D-丙氨酸更稳定。对于气态丙氨酸的 13 个稳定构象（图片显示的是全局最小值），计算的手性破坏能量位移表明，某种对映异构体的稳定强烈依赖于其构象。在所研究的结构中，只有 7 种天然存在的 L-丙氨酸是首选的，这使得我们无法确定两种手性形式的相对稳定性，从而无法解释生命体内手性起源的问题。
