Institut für Physikalische und Theoretische Chemie der Universität Bonn, Wegelerstrasse 12, 53115 Bonn, Germany.
Chemphyschem. 2001 May 18;2(5):328-31. doi: 10.1002/1439-7641(20010518)2:5<328::AID-CPHC328>3.0.CO;2-D.
A new NMR technique based on parahydrogen-induced polarisation (PHIP) is presented, that allows the catalytic enantioselective hydrogenation of prochiral substrates to be monitored (see scheme, the left-hand side arises from the hydrogenation of a prochiral alkene). The approach takes into consideration the kinetics of hydrogenation as well as the relaxation of polarisation. The use of parahydrogen temporarily generates diastereomers which can be monitored as a function of time where otherwise only enantiomers are formed.
一种新的基于氘诱导极化（PHIP）的 NMR 技术被提出，该技术可用于监测前手性底物的催化对映选择性加氢（见方案，左手边来自前手性烯烃的加氢）。该方法考虑了加氢动力学和极化弛豫。使用氘气暂时生成非对映异构体，可随时间监测，否则只能形成对映异构体。
