免疫功能正常者的原发性中枢神经系统淋巴瘤：文献综述及我们在克什米尔地区的经验

Primary CNS lymphoma in immunocompetent: a review of literature and our experience from Kashmir.

作者信息

Makhdoomi Rumana, Nayil Khursheed, Rayees Ahmad, Kirmani Altaf, Ramzan Altaf, Khalil Muhammad Baba, Dhar Anil, Besina Syed, Chanda Nasima, Lone Abdul Rashid, Qadiri Sumaira, Maqbool Muhammad

机构信息

Department of Pathology, SKIMS, Kashmir, 190011, India.

出版信息

Turk Neurosurg. 2011 Jan;21(1):39-47.

PMID:21294090

Abstract

AIM

To study the clinicopathological aspects of primary CNS lymphoma in immunocompetent patients.

MATERIAL AND METHODS

Sixteen patients with primary CNS lymphoma were analyzed for their clinico-pathological characteristics and followed-up for the treatment and subsequent management in Neurosurgery, and Medical and Radiation Oncology.

RESULTS

The fronto-parietal region was the commonest location of CNS lymphoma; four cases of cerebellar lymphoma were seen. Our patients were relatively young with a mean age of 48 years and an age range of 35-60 years. Females outnumbered males with a ratio of 2.7:1. The commonest presentation was focal neurological-deficits and features of raised intracranial pressure. All the patients histologically had diffuse large B-cell lymphoma. Radiologically, most presented as disc-enhancing lesions. Two patients had multiple lesions. Most of the patients (10) died within a mean of 4.4 months (range 2 weeks-16 months).

CONCLUSION

Primary CNS lymphoma is seen in immunocompetent patients as well. Relapse is common after treatment and the overall prognosis is unfavorable.

摘要

目的

研究免疫功能正常患者原发性中枢神经系统淋巴瘤的临床病理特征。

材料与方法

分析16例原发性中枢神经系统淋巴瘤患者的临床病理特征，并在神经外科、医学肿瘤学和放射肿瘤学领域对其治疗及后续管理进行随访。

结果

额顶叶区域是中枢神经系统淋巴瘤最常见的发病部位；发现4例小脑淋巴瘤。我们的患者相对年轻，平均年龄为48岁，年龄范围在35至60岁之间。女性多于男性，比例为2.7:1。最常见的表现是局灶性神经功能缺损和颅内压升高的症状。所有患者组织学检查均为弥漫性大B细胞淋巴瘤。影像学上，大多数表现为病灶强化。2例患者有多个病灶。大多数患者（10例）在平均4.4个月（范围为2周 - 16个月）内死亡。