大动脉弹性随增龄而变化：新的转化机制和干预措施。
Large elastic artery stiffness with aging: novel translational mechanisms and interventions.
机构信息
Department of Kinesiology and Health Promotion, University of Kentucky, Lexington, KY 40506, USA.
出版信息
Aging Dis. 2012 Dec 11;4(2):76-83. Print 2013 Apr.
Abstract
Large elastic artery stiffness is an independent predictor of age-related cardiovascular events that is attributable to structural remodeling throughout the artery. The intima, media and adventitial layers of the artery uniquely remodel with advancing age and all contribute to arterial stiffening. The specific expression of the extracellular matrix proteins collagen and elastin, and post-translational modifications of these proteins by advanced glycation end-products are key mechanisms in arterial stiffening with age and will be reviewed in the context of region-specific expression. In addition, interventions for attenuating age-related arterial stiffness and novel imaging advances for translating basic findings to older clinical populations will be discussed.
摘要
大动脉弹性硬度是与年龄相关的心血管事件的独立预测因子，其归因于整个动脉的结构重塑。随着年龄的增长，动脉的内膜、中膜和外膜层会发生独特的重塑，所有这些都会导致动脉僵硬。细胞外基质蛋白胶原和弹性蛋白的特定表达，以及这些蛋白的糖基化终产物的翻译后修饰，是动脉随年龄增长而变硬的关键机制，并将在区域特异性表达的背景下进行综述。此外，还将讨论减轻与年龄相关的动脉僵硬的干预措施和将基础研究转化为老年临床人群的新型影像学进展。
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