Colović Zavisa, Pesutić-Pisac Valdi, Poljak Nikola Kolja, Racić Goran, Cikojević Drasko, Kontić Mirko
University of Split, Split University Hospital Center, ENT Department, Split, Croatia.
Coll Antropol. 2013 Mar;37(1):151-5.
Aim of this study was to investigate the correlation of matrix metalloproteinase-9 (MMP-9) expression with histopathologic and clinical characteristics of laryngeal squamous cell carcinoma, and to assess the role of MMP-9 expression in patient survival. Study included 196 patients with squamous cell carcinoma of the larynx treated at ENT Department, Split University Hospital Centre, from January 1, 2000 till December 31, 2009. The level of MMP-9 expression showed a statistically significant correlation (p < 0.001) with the disease histopathologic grade, stage, metastatic potential, recurrence potential, and survival. Kaplan-Meier curve yielded a statistically significant survival difference (p < 0.001) among the three patient groups with different levels of MMP-9 expression. The survival curve clearly showed the MMP-9 expression as a predictor of survival to be significantly (p < 0.001) associated with survival. In this study, MMP-9 expression as a biological marker showed a potential predictive value in laryngeal squamous cell carcinoma.
本研究的目的是探讨基质金属蛋白酶-9（MMP-9）表达与喉鳞状细胞癌组织病理学及临床特征之间的相关性，并评估MMP-9表达在患者生存中的作用。该研究纳入了2000年1月1日至2009年12月31日期间在斯普利特大学医院中心耳鼻喉科接受治疗的196例喉鳞状细胞癌患者。MMP-9表达水平与疾病的组织病理学分级、分期、转移潜能、复发潜能及生存率呈统计学显著相关性（p < 0.001）。Kaplan-Meier曲线显示，MMP-9表达水平不同的三组患者之间存在统计学显著的生存差异（p < 0.001）。生存曲线清楚地表明，MMP-9表达作为生存预测指标与生存率显著相关（p < 0.001）。在本研究中，MMP-9表达作为一种生物标志物在喉鳞状细胞癌中显示出潜在的预测价值。
