a Department of Reproduction, Obstetrics and Herd Health, Faculty of Veterinary Medicine , Ghent University , Merelbeke , Belgium.
Vet Q. 2013 Dec;33(4):234-41. doi: 10.1080/01652176.2013.800250. Epub 2013 May 22.
In the past decade, mesenchymal stem cells (MSC) have received much attention in equine veterinary medicine. The first therapeutic use of equine MSC was reported in 2003. Since then, the clinical application of MSC has been exploding with thousands of horses now treated worldwide. At present, MSC are mainly used in veterinary medicine to treat musculoskeletal diseases based on their ability to differentiate into various tissues of mesodermal origin. This is in marked contrast to human medicine, where MSC therapies are primarily focused on immune-mediated, inflammatory, and ischemic diseases. In this review, both orthopedic as well as non-orthopedic clinical applications of equine MSC are discussed. A brief overview is provided on the potential of MSC for non-orthopedic injuries with emphasis on those diseases, which occur in both humans and horses.
在过去的十年中，间充质干细胞（MSC）在兽医领域受到了广泛关注。2003 年首次报道了马 MSC 的治疗用途。自那时以来，MSC 的临床应用呈爆炸式增长，现在全球已有数千匹马接受了治疗。目前，MSC 主要用于兽医领域治疗肌肉骨骼疾病，这基于其分化为中胚层来源的各种组织的能力。这与人类医学形成鲜明对比，人类医学中的 MSC 疗法主要集中在免疫介导、炎症和缺血性疾病上。在这篇综述中，讨论了马 MSC 在骨科和非骨科临床应用。简要概述了 MSC 治疗非骨科损伤的潜力，重点介绍了那些在人类和马中都发生的疾病。
