特立尼达浸润性宫颈鳞癌中的人乳头瘤病毒基因型。
Human papillomavirus genotypes in invasive cervical squamous cell carcinoma in Trinidad.
机构信息
Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago.
出版信息
Rev Panam Salud Publica. 2013 Apr;33(4):267-70. doi: 10.1590/s1020-49892013000400005.
OBJECTIVE
To determine the relative contribution of known high-risk human papillomavirus (HPV) genotypes to the occurrence of cervical cancers in Trinidad.
METHODS
The distribution of HPV genotypes in cases of invasive cervical squamous cell carcinoma in Trinidad was investigated. This study was a follow-up to an investigation of HPV genotypes in 310 nonsymptomatic women in Trinidad. The latter study showed that cervical HPV prevalence and heterogeneity of genotypes were high in the study population; notably, the genotypes targeted by the available HPV prophylactic vaccines were not the most common types.
RESULTS
The current study of 85 cases of invasive cervical squamous cell carcinomas demonstrated that the previously observed heterogeneity in HPV genotype distribution is lost in cases of invasive cervical cancer, with the vaccine-targeted HPV types HPV 16 and HPV 18 becoming the most prevalent.
CONCLUSIONS
HPV 16 and HPV 18 were the primary HPV genotypes associated with cases of invasive squamous cell carcinoma in the current Trinidad study. This strong association leads us to conclude that the HPV vaccines targeting HPV 16 and HPV 18 may contribute to reducing the cervical cancer burden in Trinidad.
目的
确定已知高危型人乳头瘤病毒（HPV）基因型在特立尼达宫颈癌发病中的相对贡献。
方法
研究调查了特立尼达浸润性宫颈鳞状细胞癌病例中 HPV 基因型的分布。本研究是对特立尼达 310 例无症状女性 HPV 基因型进行调查的后续研究。后者的研究表明，研究人群中宫颈 HPV 患病率和基因型的异质性很高；值得注意的是，现有 HPV 预防性疫苗针对的基因型并非最常见的类型。
结果
目前对 85 例浸润性宫颈鳞状细胞癌的研究表明，以前观察到的 HPV 基因型分布异质性在浸润性宫颈癌病例中消失，疫苗针对的 HPV 类型 HPV 16 和 HPV 18 成为最常见的类型。
结论
HPV 16 和 HPV 18 是目前特立尼达研究中与浸润性鳞状细胞癌相关的主要 HPV 基因型。这种强烈的关联使我们得出结论，针对 HPV 16 和 HPV 18 的 HPV 疫苗可能有助于降低特立尼达的宫颈癌负担。
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