高IgE水平的慢性荨麻疹：口服环孢素A治疗的初步结果
Chronic urticaria with high IgE levels: first results on oral cyclosporine A treatment.
作者信息
Guaragna M A, Albanesi M, Stefani S, Franconi G, Di Stanislao C, Paparo Barbaro S
机构信息
Department of Clinical and Molecular Medicine, Faculty of Medicine and Psycology, Sapienza University of Rome, Rome, Italy.
出版信息
Clin Ter. 2013;164(2):115-8. doi: 10.7417/CT.2013.1528.
INTRODUCTION
Chronic Urticaria is a difficult to define condition from the nosographic standpoint, with complex pharmacological management, that heavily impacts the life of the patient. Some forms show not to be responsive to anti H1 anti-histaminic and require other treatments. One of these can be the treatment with Cyclosporine A (CsA).
MATERIALS AND METHODS
This study, open and sequential, reports the results of short-term treatment over a sample of adults (21 patients) of both sexes, all suffering from chronic urticaria with IgE levels higher than 200 mU/ml treated with 4 mg/kg/die of CsA.
RESULTS
The results obtained show a reduction in the levels of total IgE and a significant improvement in symptoms; there were no adverse effects.
CONCLUSIONS
Cyclosporine is an excellent treatment for chronic urticaria because it reduces the activity of T lymphocytes and reduction of the histamine release from the mast cells and basophils.
引言
从疾病分类学角度来看，慢性荨麻疹是一种难以定义的病症，其药物治疗复杂，对患者生活影响重大。某些类型的慢性荨麻疹对H1抗组胺药无反应，需要其他治疗方法。环孢素A（CsA）治疗即为其中一种。
材料与方法
本研究为开放性序贯研究，报告了对21例成年男女慢性荨麻疹患者进行短期治疗的结果，所有患者IgE水平高于200 mU/ml，接受4 mg/kg/日的CsA治疗。
结果
所得结果显示总IgE水平降低，症状显著改善；未出现不良反应。
结论
环孢素是治疗慢性荨麻疹的一种优秀药物，因为它可降低T淋巴细胞活性，减少肥大细胞和嗜碱性粒细胞释放组胺。
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