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皮肤鳞状细胞癌:简要综述。

Squamous cell carcinoma of skin: a brief review.

作者信息

Rahimi S

机构信息

Consultant Histopathologist, Pathology Centre, Queen Alexandra Hospital, Southwick Hill Road, Cosham, Portsmouth PO6 3LY, UK.

出版信息

Clin Ter. 2013;164(2):143-7. doi: 10.7417/CT.2013.1534.

DOI:10.7417/CT.2013.1534
PMID:23698209
Abstract

Cutaneous squamous cell carcinoma (SCC) is the second most common skin cancer in Caucasians, most frequently occurring on sun-exposed areas of the body. Most SCCs are treated surgically, either by excision or Mohs micrographic surgery. Despite the large amount of English literature with regard to cutaneous SCC in many instances the surgical treatment is not appropriate resulting in recurrences and/ or metastasis. The following brief review highlights the histology, molecular biology and surgical treatment of skin SCC.

摘要

皮肤鳞状细胞癌(SCC)是白种人中第二常见的皮肤癌,最常发生于身体暴露于阳光的部位。大多数皮肤鳞状细胞癌通过手术治疗,要么切除,要么采用莫氏显微外科手术。尽管有大量关于皮肤鳞状细胞癌的英文文献,但在很多情况下,手术治疗并不合适,会导致复发和/或转移。以下简要综述重点介绍皮肤鳞状细胞癌的组织学、分子生物学及手术治疗。

相似文献

1
Squamous cell carcinoma of skin: a brief review.皮肤鳞状细胞癌:简要综述。
Clin Ter. 2013;164(2):143-7. doi: 10.7417/CT.2013.1534.
2
Expression of p53 in the evolution of squamous cell carcinoma: correlation with the histology of the lesion.p53在鳞状细胞癌演变过程中的表达:与病变组织学的相关性。
J Am Acad Dermatol. 2007 Oct;57(4):669-76. doi: 10.1016/j.jaad.2007.04.025.
3
Combined sentinel lymphadenectomy and mohs micrographic surgery for high-risk cutaneous squamous cell carcinoma.前哨淋巴结切除术联合莫氏显微外科手术治疗高危皮肤鳞状细胞癌
J Am Acad Dermatol. 2000 Sep;43(3):483-8. doi: 10.1067/mjd.2000.106367.
4
Mohs surgery for squamous cell carcinoma.Mohs 手术治疗鳞状细胞癌。
Dermatol Clin. 2011 Apr;29(2):161-74, vii. doi: 10.1016/j.det.2011.02.006.
5
Cutaneous squamous cell carcinoma in human immunodeficiency virus-infected patients. A study of epidemiologic risk factors, human papillomavirus, and p53 expression.人类免疫缺陷病毒感染患者的皮肤鳞状细胞癌。一项关于流行病学危险因素、人乳头瘤病毒和p53表达的研究。
Arch Dermatol. 1997 May;133(5):577-83.
6
Mohs micrographic surgery of the nail unit and squamous cell carcinoma.甲单位及鳞状细胞癌的莫氏显微外科手术
Dermatol Surg. 2001 Mar;27(3):246-51.
7
Immunophenotypic analysis of the p53 gene in non-melanoma skin cancer and correlation with apoptosis and cell proliferation.非黑色素瘤皮肤癌中p53基因的免疫表型分析及其与细胞凋亡和细胞增殖的相关性
J Eur Acad Dermatol Venereol. 2005 Mar;19(2):180-6. doi: 10.1111/j.1468-3083.2005.01094.x.
8
Surgical margins in the treatment of nonmelanoma skin cancer and mohs micrographic surgery.非黑色素瘤皮肤癌治疗中的手术切缘与莫氏显微外科手术
Curr Surg. 2005 Sep-Oct;62(5):518-26. doi: 10.1016/j.cursur.2005.01.003.
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Treatment of cutaneous squamous cell carcinoma with perineural invasion using Mohs micrographic surgery: report of two cases and review of the literature.应用莫氏显微外科手术治疗伴神经周围浸润的皮肤鳞状细胞癌:2例报告及文献复习
Dermatol Surg. 2009 Oct;35(10):1559-66. doi: 10.1111/j.1524-4725.2009.01276.x. Epub 2009 Jul 28.
10
Gene expression patterns of normal human skin, actinic keratosis, and squamous cell carcinoma: a spectrum of disease progression.正常人皮肤、光化性角化病和鳞状细胞癌的基因表达模式:疾病进展的一个谱系
Arch Dermatol. 2010 Mar;146(3):288-93. doi: 10.1001/archdermatol.2009.378.

引用本文的文献

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The role of EphA7 in different tumors.EphA7 在不同肿瘤中的作用。
Clin Transl Oncol. 2022 Jul;24(7):1274-1289. doi: 10.1007/s12094-022-02783-1. Epub 2022 Feb 2.
2
CD4+ CD25+ regulatory T-cells role in tumor microenvironment of the squamous cell carcinoma.CD4+ CD25+ 调节性 T 细胞在鳞状细胞癌肿瘤微环境中的作用。
Rom J Morphol Embryol. 2021 Jan-Mar;62(1):249-253. doi: 10.47162/RJME.62.1.25.
3
Aberrant DNA Methylation in Keratoacanthoma.角化棘皮瘤中的异常DNA甲基化
PLoS One. 2016 Oct 27;11(10):e0165370. doi: 10.1371/journal.pone.0165370. eCollection 2016.
4
Decreased expression of microRNA-20a promotes tumor progression and predicts poor prognosis of cutaneous squamous cell carcinoma.微小RNA-20a表达降低促进皮肤鳞状细胞癌的肿瘤进展并预示不良预后。
Int J Clin Exp Pathol. 2015 Sep 1;8(9):11446-51. eCollection 2015.
5
TIPE2 regulates tumor-associated macrophages in skin squamous cell carcinoma.TIPE2在皮肤鳞状细胞癌中调节肿瘤相关巨噬细胞。
Tumour Biol. 2016 Apr;37(4):5585-90. doi: 10.1007/s13277-015-4388-9. Epub 2015 Nov 15.
6
Lgr5-positive cells are cancer stem cells in skin squamous cell carcinoma.Lgr5阳性细胞是皮肤鳞状细胞癌中的癌症干细胞。
Tumour Biol. 2014 Nov;35(11):11605-12. doi: 10.1007/s13277-014-2488-6. Epub 2014 Aug 19.
7
MiR-20a inhibits cutaneous squamous cell carcinoma metastasis and proliferation by directly targeting LIMK1.微小RNA-20a通过直接靶向LIMK1抑制皮肤鳞状细胞癌的转移和增殖。
Cancer Biol Ther. 2014 Oct;15(10):1340-9. doi: 10.4161/cbt.29821. Epub 2014 Jul 14.